CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8812
Family Name Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-methyl-3-[[4-(pyridin-4-ylmethoxy)benzoyl]amino]phenyl]-5-morpholin-4-ylbenzamide family
No. of Seeds 2 No. of Other Members 5
Family Centroid CFAMM00390753 Functional Category Bioactive
Superfamily Calcium-activated potassium channel subunit alpha-1 Ligand AVE0118 Superfamily
Class Class 656

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Smoothened homolog Inhibitor LDE225 Family 3 76
MK-6096 family 3 69
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Histamine H3 receptor ligand SureCN2784306 family 5 3
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Mitogen-activated protein kinase 14 inhibitor N-[4-methyl-3-[[... 2 2
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 10 15
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Collagenase 3 inhibitor 4-[4-[[5-(2-ethoxyethyl)-2,4,6-trioxo-... 3 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Motilin receptor ligand SureCN2768193 family 2 1
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Angiopoietin-1 receptor ligand SureCN1939461 family 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 6 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Coagulation factor X inhibitor 3-Oxybenzamide 15 family 1 1
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00390753 CHEMBL183999 Bioactive 3-fluoro-N-[4-methyl-3-[[4-(pyridin-4-ylmethoxy)benzoyl]amino]phenyl]-5-morpholin-4-ylbenzamide
CFAMM00390751 CHEMBL184012 Bioactive N-[4-methyl-3-[[4-(pyridin-2-ylmethoxy)benzoyl]amino]phenyl]-2-morpholin-4-ylpyridine-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26413 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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