CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8827
Family Name Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[5-methyl-2-oxo-4-[4-[(pyridin-2-ylamino)methyl]piperidin-1-yl]pyrimidin-1-yl]-2-(phenylmethoxycarbonylamino)propanoic acid family
No. of Seeds 4 No. of Other Members 5
Family Centroid CFAMM00390884 Functional Category Bioactive
Superfamily Calcitonin gene-related peptide type 1 receptor and Integrin beta-3 Binder Superfamily
Class Class 3274

Cousin Family NamesSeedsMembers
HIV-1 protease Inhibitor Atazanavir Family 16 58
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-cyc... 3 6
Integrin beta-3 and Integrin alpha-V inhibitor SureCN547914 fa... 8 32
Integrin alpha-V and Integrin beta-5 inhibitor SureCN6563167 f... 2 10
Neutrophil elastase inhibitor SureCN7284457 family 4 6
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(4-ethox... 4 5
Integrin beta-3 and Integrin alpha-V inhibitor 2-(2,3-dihydro-... 13 1
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Integrin beta-3 and Integrin alpha-V inhibitor (3R)-3-quinolin... 6 8
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 8 8
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[[4-[2-(... 3 3
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[6-m... 13 12
Integrin beta-3 and Integrin alpha-V inhibitor SureCN6359092 f... 9 5
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN2059024 f... 6 3
Pol polyprotein inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-N-... 7 3
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-2-[[(1R,4S... 3 0
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-2-(benzene... 3 2
Metabotropic glutamate receptor 5 ligand AGN-PC-075X3Y family 2 6
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(2,6-di... 14 8
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(4-fluo... 7 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(2,6-di... 6 5
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5351665 fa... 5 4
Integrin beta-3 and Integrin alpha-V inhibitor SureCN2842307 f... 4 0
Pol polyprotein inhibitor AC1LAHRX family 4 0
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Integrin beta-1 and Integrin alpha-5 inhibitor SureCN14453479 ... 3 5
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(3-fluor... 10 0
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[4-(... 3 0
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[[2-[(... 3 1
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Protein-glutamine gamma-glutamyltransferase 2 and Coagulation ... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00390884 CHEMBL45971 Bioactive (2S)-3-[5-methyl-2-oxo-4-[4-[(pyridin-2-ylamino)methyl]piperidin-1-yl]pyrimidin-1-yl]-2-(phenylmethoxycarbonylamino)propanoic acid
CFAMM00390882 CHEMBL45621 Bioactive (2S)-3-[5-methyl-2-oxo-4-[4-(pyridin-2-ylamino)piperidin-1-yl]pyrimidin-1-yl]-2-(phenylmethoxycarbonylamino)propanoic acid
CFAMM00390888 CHEMBL186085 Bioactive SureCN6421344
CFAMM00390886 CHEMBL184484 Bioactive (2S)-2-(phenylmethoxycarbonylamino)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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