CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8830
Family Name 5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine receptor 1A ligand SureCN5315176 family
No. of Seeds 2 No. of Other Members 18
Family Centroid CFAMM00042424 Functional Category Bioactive
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Binder Superfamily 18
Class Class 208

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Macrophage colony-stimulating factor 1 Inhibitor ABT-869 Family 8 56
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Cyclin-dependent kinase 2 Inhibitor N-(5-cyclopropyl-1h-pyrazo... 6 62
Aurora kinase B and Aurora kinase C Inhibitor PHA-680632 Family 5 72
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 19 12
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(1h... 2 12
Glycogen synthase kinase-3 beta Inhibitor (e)-n-(6-(prop-1-eny... 3 0
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Cytochrome P450 3A4 Inhibitor 5-(2-phenethylpiperazin-1-yl)-1h... 12 35
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 29
5-hydroxytryptamine receptor 3A ligand SureCN8035577 family 5 4
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Serine/threonine-protein kinase 17A and Myosin light chain kin... 3 7
Tyrosine-protein kinase ITK/TSK inhibitor (3Z)-3-(6-methylindo... 2 40
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-075CD... 2 8
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 4 3
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
cAMP-dependent protein kinase catalytic subunit PRKX and cGMP-... 1 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 5
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 2
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
Rho-associated protein kinase 2 inhibitor 2-[(3S,4R)-4-(4-fluo... 9 0
Platelet-derived growth factor receptor beta and Ribosomal pro... 1 1
Serine/threonine-protein kinase PLK4 inhibitor 4-[(E)-2-[6-[(E... 2 3
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Serine/threonine-protein kinase Chk1 inhibitor SureCN4298966 f... 10 1
Serine/threonine-protein kinase Chk1 inhibitor 5-[(2S)-3-amino... 4 6
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 10 9
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 4 4
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Histone deacetylase 1 inhibitor N-hydroxy-N',N'-bis[2-(1H-inda... 1 0
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 2
Melanocyte-stimulating hormone receptor and Melanocortin recep... 3 7
Serine/threonine-protein kinase D1 inhibitor 3-[5-[3-bromo-4-(... 1 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor py... 1 3
Rho-associated protein kinase 2 and Cytochrome P450 3A4 inhibi... 3 5


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26814 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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