CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8836
Family Name Adenosine deaminase inhibitor AGN-PC-00FYYU family
No. of Seeds 4 No. of Other Members 5
Family Centroid CFAMM00390935 Functional Category Bioactive
Superfamily Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Superfamily
Class Class 920

Cousin Family NamesSeedsMembers
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Adenosine receptor A2a Ligand MRE-0094 Family 10 108
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
TOK-001 family 2 7
GDC-0349 family 44 77
C-Jun N-terminal kinase Inhibitor CC-930 Family 2 9
4-hydroxyphenylpyruvate dioxygenase Inhibitor BMS-433771 Family 1 2
PF-4217903 family 14 65
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 7 72
Thromboxane-A synthase Inhibitor CGS-13080 Family 3 19
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Adenosine receptor A1 and Adenosine receptor A2a Ligand GW-328... 26 94
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-[(4-... 15 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 12 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 2
Adenosine receptor A2a and Adenosine receptor A3 Ligand 2-(3''... 8 10
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Inositol 1,4,5-trisphosphate receptor type 3 Ligand 5'-deoxy-5... 11 8
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Uracil nucleotide/cysteinyl leukotriene receptor ligand azane;... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 13
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inh... 7 6
S-methyl-5'-thioadenosine phosphorylase inhibitor SureCN997478... 8 0
C-X-C chemokine receptor type 4 and Envelope glycoprotein gp16... 2 2
Sorbitol dehydrogenase inhibitor SureCN6335187 family 2 6
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 2 2
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Transient receptor potential cation channel subfamily V member... 4 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 0
Dual specificity protein kinase TTK inhibitor 4-[[2-(2-methyl-... 1 0
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Adenosylhomocysteinase inhibitor Carbocyclic 3-deazaadenosine ... 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 1 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor (2S)-2-[[9-p... 4 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00390936 CHEMBL322906 Bioactive (2R,3R)-3-(4-aminoimidazo[4,5-c]pyridin-1-yl)-1-fluorononan-2-ol
CFAMM00390935 CHEMBL18496 Bioactive AGN-PC-00FYYU
CFAMM00390939 CHEMBL433164 Bioactive SureCN3926507

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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