CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8848
Family Name D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyanophenyl)-N-(3-methylphenyl)- family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00390995 Functional Category Bioactive with Natural Product
Superfamily Serine/threonine-protein kinase mTOR Inhibitor CC-223 Superfamily
Class Class 1230

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Delta-type opioid receptor Ligand Sb 227122 Family 7 5
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Integrin beta-3 Inhibitor L-767679 Family 3 6
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Transient receptor potential cation channel subfamily V member... 6 33
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Androgen receptor Ligand YM-175735 Family 30 129
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Telomerase reverse transcriptase Inhibitor 2,7-bis[2-(piperidi... 6 8
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Sphingosine kinase 2 Inhibitor (r)-2-amino-4-hydroxy-n-(4-octy... 3 9
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Leukotriene A-4 hydrolase Inhibitor SA-6541 Family 4 32
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 3 3
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Cathepsin K and Cathepsin B inhibitor AGN-PC-01Z23J family 2 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 1
Cathepsin K and Cathepsin L1 inhibitor 1-[(2S)-1-[[cyano(methy... 2 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Melanin-concentrating hormone receptor 1 ligand 1-[2-[4-(3-cya... 3 2
Ribosyldihydronicotinamide dehydrogenase [quinone] and Melaton... 1 3
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 11 9
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 3
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Substance-P receptor and Potassium voltage-gated channel subfa... 5 0
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 2
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Dipeptidyl peptidase 4 inhibitor 4-[4-[(3S,5S)-5-(1,3-thiazoli... 3 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 0
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
C-X-C chemokine receptor type 3 and Muscarinic acetylcholine r... 1 0
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 3
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 7 ligand 2-[4-[4-(2-oxo-1,3,4,5-t... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
C-C chemokine receptor type 3 ligand AGN-PC-073RIP family 2 4
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Caspase-8 and Caspase-3 inhibitor (3S)-3-[[(2S)-4-methyl-2-[[2... 3 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 5
Dipeptidyl peptidase 4 inhibitor 4-[[(3S,5S)-5-[(2S)-2-cyanopy... 4 12
Transient receptor potential cation channel subfamily V member... 1 1
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Dipeptidyl peptidase 4 inhibitor (2S,4S)-1-[2-[[1-[4-cyano-2-(... 2 0
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 5
Cathepsin K and Cathepsin B inhibitor AGN-PC-076LFZ family 1 0
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor 3-[(3S)... 1 0
Collagenase 3 and Interstitial collagenase inhibitor (2R,3S)-N... 1 0
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-[2-... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Amyloid beta A4 protein inhibitor (2S,3R)-3-(2-methylpropyl)-N... 1 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide de... 2 4
C-X-C chemokine receptor type 3 ligand 3-[3,5-bis(trifluoromet... 3 5
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 1 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
Acyl-CoA:cholesterol acyltransferase inhibitor N-[2,6-di(propa... 1 2
Voltage-dependent L-type calcium channel subunit alpha-1S liga... 1 0
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00390995 CHEMBL216450 Bioactive 1-Piperidineacetamide, 4-(2-cyanophenyl)-N-(3-methylphenyl)-

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24631 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543