CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8849
Family Name Sphingosine 1-phosphate receptor 5 and Sphingosine 1-phosphate receptor 1 ligand [(2R)-2-amino-2-(6-octyl-1H-benzimidazol-2-yl)ethyl] dihydrogen phosphate;methyl 2,2,2-trifluoroacetate family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00391006 Functional Category Bioactive
Superfamily Vascular endothelial growth factor receptor 2 Ligand 6-(1h-benzoimidazol-2-yl)-benzocyclohepten-7-one Superfamily
Class Class 1983

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Tryptase Inhibitor Babim Family 12 90
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0


External ID

Functional Category

Molecule Name

CFAMM00391005 CHEMBL361915 Bioactive [(2S)-2-amino-2-(6-octyl-1H-benzimidazol-2-yl)ethyl] dihydrogen phosphate;methyl 2,2,2-trifluoroacetate
CFAMM00391009 CHEMBL1910653 Bioactive [(2R)-2-amino-2-(6-octyl-1H-benzimidazol-2-yl)ethyl] dihydrogen phosphate;2,2,2-trifluoroacetic acid
CFAMM00391008 CHEMBL537849 Bioactive AGN-PC-07C10R
CFAMM00391006 CHEMBL185491 Bioactive [(2R)-2-amino-2-(6-octyl-1H-benzimidazol-2-yl)ethyl] dihydrogen phosphate;methyl 2,2,2-trifluoroacetate

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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