CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8855
Family Name Vascular endothelial growth factor receptor 2 ligand urea deriv. 20 family
No. of Seeds 3 No. of Other Members 9
Family Centroid CFAMM00391042 Functional Category Bioactive
Superfamily Tyrosine-protein kinase BTK Inhibitor CC-292 Superfamily
Class Class 1334

Cousin Family NamesSeedsMembers
Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
Transient receptor potential cation channel subfamily V member... 15 457
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
Tyrosine-protein kinase BTK Inhibitor CC-292 Family 6 10
JAK Inhibitor Momelotinib Family 33 83
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Vascular endothelial growth factor receptor 2 ligand urea deri... 2 0
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Nicotinamide phosphoribosyltransferase and Cytochrome P450 2C9... 4 5
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 5
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-[3-(2-hydroxyeth... 2 1
Tyrosine-protein kinase ZAP-70 inhibitor AGN-PC-07CO7Z family 1 0
Protein-tyrosine kinase 2-beta inhibitor 4-N-[(1R,2R)-2-(dimet... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00391046 CHEMBL188997 Bioactive urea deriv. 18
CFAMM00391044 CHEMBL189354 Bioactive urea deriv. 19
CFAMM00391042 CHEMBL185716 Bioactive urea deriv. 20

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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