CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM887
Family Name Poly [ADP-ribose] polymerase 1 inhibitor 2-(3-chlorophenyl)-1H-benzimidazole-4-carboxamide family
No. of Seeds 4 No. of Other Members 38
Family Centroid CFAMM00316892 Functional Category Bioactive
Superfamily Prostaglandin E synthase and Cytochrome P450 2C9 Binder Superfamily
Class Class 3039

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Tubulin beta chain Inhibitor Mebendazole Family 12 84
CC-486 family 7 103
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Adenosine receptor A1 ligand SureCN10614388 family 5 1
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
Histamine H4 receptor ligand SureCN602132 family 1 8
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Poly [ADP-ribose] polymerase 1 inhibitor ethyl 4-(4-carbamoyl-... 2 15
Poly [ADP-ribose] polymerase 1 inhibitor SureCN6202744 family 4 2
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methyl... 10 19
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 6 2
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Prothrombin inhibitor AGN-PC-09QLAK family 10 2
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Histamine H3 receptor ligand SureCN2878688 family 8 1
5-hydroxytryptamine receptor 4 ligand AGN-PC-00PM3Y family 4 3
Serine/threonine-protein kinase Chk2 inhibitor SureCN3922132 f... 3 2
Coagulation factor X inhibitor SureCN8289965 family 4 5
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Prostaglandin E synthase and Cytochrome P450 2C9 inhibitor 7-b... 1 7
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 2
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 2 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Prostaglandin E synthase inhibitor 2-(2-chloro-6-fluorophenyl)... 9 1
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 10 1
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Dipeptidyl peptidase 4 inhibitor SureCN5776796 family 1 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor 2-[4-(1,2-oxazol-5-yl... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor 2-[4-(5-sulfanylidene... 1 1
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-077DC5 family 2 2
Sonic hedgehog protein and Cytochrome P450 2C9 inhibitor AGN-P... 1 0
Sodium/hydrogen exchanger 1 inhibitor N-(diaminomethylidene)-2... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00316892 CHEMBL132947 Bioactive 2-(3-chlorophenyl)-1H-benzimidazole-4-carboxamide
CFAMM00316895 CHEMBL131891 Bioactive SureCN3341660
CFAMM00316920 CHEMBL1092226 Bioactive SureCN4970604
CFAMM00316899 CHEMBL335226 Bioactive 2-(2-chlorophenyl)-1H-benzimidazole-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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