CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8871
Family Name Corticotropin-releasing factor receptor 1 and Corticotropin-releasing factor receptor 2 ligand Pyridopyrazinone, 2a family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00391205 Functional Category Bioactive
Superfamily Corticotropin-releasing factor receptor 1 and Beta-lactamase Binder Superfamily 3
Class Class 822

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Survival motor neuron protein and Microtubule-associated prote... 2 14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 2 0
Corticotropin-releasing factor receptor 1 ligand 3,6-diethyl-5... 7 8
Fatty-acid amide hydrolase 1 inhibitor [4-(4-methoxyphenyl)pip... 1 1
Toll-like receptor 7 ligand 4-amino-1-[[6-(2-pyrrolidin-1-ylet... 2 5
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 5 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00G4OY... 3 0
Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family 2 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 16 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 18 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 1
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00391206 CHEMBL228168 Bioactive Pyridopyrazine, 2b
CFAMM00391205 CHEMBL186097 Bioactive Pyridopyrazinone, 2a
CFAMM00391210 CHEMBL390763 Bioactive Pteridine, 2d
CFAMM00391208 CHEMBL188861 Bioactive 8-[butyl(ethyl)amino]-4-(6-methoxy-2-methylpyridin-3-yl)-6-methyl-1,3-dihydropyrido[2,3-b]pyrazin-2-one;2,2,2-trifluoroacetic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27036 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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