CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8877
Family Name Corticotropin-releasing factor receptor 1 ligand 8-[butyl(ethyl)amino]-4-(2,4-dichlorophenyl)-6-methyl-1,3-dihydropyrido[2,3-b]pyrazin-2-one family
No. of Seeds 2 No. of Other Members 6
Family Centroid CFAMM00391278 Functional Category Bioactive
Superfamily Corticotropin-releasing factor receptor 1 and Transketolase Binder Superfamily
Class Class 375

Cousin Family NamesSeedsMembers
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 2
Fatty-acid amide hydrolase 1 inhibitor 3-[(3S)-1-[4-(5-chlorot... 2 1
Corticotropin-releasing factor receptor 1 ligand 3-chloro-4-[8... 7 1
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Corticotropin-releasing factor receptor 1 ligand SureCN6323029... 2 13


External ID

Functional Category

Molecule Name

CFAMM00391282 CHEMBL190488 Bioactive CHEMBL190488
CFAMM00391278 CHEMBL186203 Bioactive 8-[butyl(ethyl)amino]-4-(2,4-dichlorophenyl)-6-methyl-1,3-dihydropyrido[2,3-b]pyrazin-2-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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