CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8879
Family Name Corticotropin-releasing factor receptor 1 ligand 3-chloro-4-[8-(dipropylamino)-6-methyl-2-oxo-1,3-dihydropyrido[2,3-b]pyrazin-4-yl]benzonitrile family
No. of Seeds 7 No. of Other Members 1
Family Centroid CFAMM00391292 Functional Category Bioactive
Superfamily Corticotropin-releasing factor receptor 1 and Transketolase Binder Superfamily
Class Class 375

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 16 295
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Reverse transcriptase Inhibitor PT-109 Family 6 7
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 2
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
Corticotropin-releasing factor receptor 1 ligand AGN-PC-008HTV... 2 1
Corticotropin-releasing factor receptor 1 ligand 8-[butyl(ethy... 2 6
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Histamine H4 receptor and Histamine H1 receptor ligand 6-chlor... 1 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2


External ID

Functional Category

Molecule Name

CFAMM00391287 CHEMBL189196 Bioactive 3-chloro-4-[8-[cyclobutylmethyl(propyl)amino]-6-methyl-2-oxo-1,3-dihydropyrido[2,3-b]pyrazin-4-yl]benzonitrile
CFAMM00391292 CHEMBL186241 Bioactive 3-chloro-4-[8-(dipropylamino)-6-methyl-2-oxo-1,3-dihydropyrido[2,3-b]pyrazin-4-yl]benzonitrile
CFAMM00391285 CHEMBL187410 Bioactive AGN-PC-008S0G
CFAMM00391291 CHEMBL187987 Bioactive 4-[8-[butyl(ethyl)amino]-6-methyl-2-oxo-1,3-dihydropyrido[2,3-b]pyrazin-4-yl]-3-chlorobenzonitrile
CFAMM00391290 CHEMBL433592 Bioactive AGN-PC-006G3Q
CFAMM00391289 CHEMBL186517 Bioactive AGN-PC-0059GX
CFAMM00391288 CHEMBL364883 Bioactive AGN-PC-00FGB4

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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