CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8884
Family Name Pol polyprotein inhibitor AC1LADII family
No. of Seeds 12 No. of Other Members 1
Family Centroid CFAMM00391365 Functional Category Bioactive
Superfamily Pol polyprotein Binder Superfamily 34
Class Class 3076

Cousin Family NamesSeedsMembers
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Plasmepsin-2 Inhibitor KNI-10232 Family 8 36
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-3-hydroxy-6... 40 29
Pol polyprotein inhibitor AC1LAK4B family 16 11
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-3-hydroxy-6... 11 8
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
Pol polyprotein inhibitor AC1L9R8S family 5 4
Pol polyprotein inhibitor (2R,3R,4R,5R)-3,4-dihydroxy-N-[(2S)-... 22 10
Pol polyprotein inhibitor (2S)-4-benzyl-1-[(2S,4R)-4-benzyl-2-... 10 4
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 4
Pol polyprotein inhibitor (2R,3R,4R,5R)-2,3,4-trihydroxy-N,N'-... 3 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Pol polyprotein inhibitor (2R)-2-benzyl-5-[(3S,5R)-3-benzyl-5-... 11 5
Pol polyprotein inhibitor 3-[[(3S,5R)-5-benzyl-1-[(2S,4R)-4-be... 4 0
Pol polyprotein inhibitor (2R,4S)-5-[(5R)-3-[(3-aminophenyl)me... 4 2
Beta-secretase 1 inhibitor (2S)-2-[(3R)-3-acetamido-3-(2-methy... 3 0
Pol polyprotein inhibitor SureCN3530080 family 3 8
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-5-benzyl-3-... 3 0
Pol polyprotein inhibitor L-689,502 family 17 2
Pol polyprotein inhibitor SDZ PRI 053 family 8 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 4
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5S)-3-hydroxy-5... 4 12
Pol polyprotein inhibitor AC1NS2O6 family 3 0
Pol polyprotein inhibitor AC1L9R8I family 1 0
Pol polyprotein inhibitor AC1L9R8M family 4 1
Pol polyprotein inhibitor (3S,5R)-1-[(2S,4R)-6-amino-4-benzyl-... 1 0
Pol polyprotein inhibitor (2R,3R,4R,5R)-2,5-bis[(2-fluoropheny... 4 0
Pol polyprotein inhibitor (2R,3R,4R,5R)-3,4-dihydroxy-N-[(1S,2... 2 0
Pol polyprotein inhibitor (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5... 2 0
Pol polyprotein inhibitor (2R)-5-[(3S,5R)-3,5-dibenzyl-2-oxopy... 3 0
Plasmepsin-2 and Plasmepsin-1 inhibitor (2R,3R,4R,5R)-2,5-bis[... 2 2
Pol polyprotein inhibitor AC1LADB2 family 1 0
Pol polyprotein inhibitor (2R,4S)-2-benzyl-5-[2-(tert-butylsul... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00391366 CHEMBL278928 Bioactive (2R,4S)-2-benzyl-5-[(3S)-3,5-dibenzyl-1,1-dioxo-1,2,5-thiadiazolidin-2-yl]-4-hydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
CFAMM00391359 CHEMBL360398 Bioactive (2R)-2-benzyl-5-[(3S,5R)-3,5-dibenzyl-2-oxopyrrolidin-1-yl]-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-4-oxopentanamide
CFAMM00391365 CHEMBL263072 Bioactive AC1LADII
CFAMM00391364 CHEMBL262204 Bioactive imidazolidin-2-one analog
CFAMM00391357 CHEMBL363187 Bioactive (2R,4S)-2-benzyl-5-[(3S)-3,5-dibenzyl-2-oxopyrrolidin-1-yl]-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
CFAMM00391363 CHEMBL187057 Bioactive (2R,4S)-2-benzyl-5-[(3S,5R)-5-benzyl-2-oxo-3-prop-2-enylpyrrolidin-1-yl]-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
CFAMM00391369 CHEMBL186668 Bioactive (2R,4S)-2-benzyl-5-[(5R)-5-benzyl-3-[(3-cyanophenyl)methyl]-2-oxopyrrolidin-1-yl]-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
CFAMM00391362 CHEMBL186347 Bioactive (2R,4S)-2-benzyl-5-[5-benzyl-3-[(3-fluorophenyl)methyl]-2-oxoimidazolidin-1-yl]-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
CFAMM00391368 CHEMBL325038 Bioactive AC1LAK5H
CFAMM00391361 CHEMBL414156 Bioactive (2R,4S)-2-benzyl-5-(3,5-dibenzyl-2-oxoimidazolidin-1-yl)-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
CFAMM00391367 CHEMBL365479 Bioactive (2R,4S)-2-benzyl-5-[(5R)-5-benzyl-3-[(4-cyanophenyl)methyl]-2-oxopyrrolidin-1-yl]-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
CFAMM00391360 CHEMBL362095 Bioactive (2R,4S)-5-[(3S,5R)-3-[[3-(2-amino-2-oxoethyl)phenyl]methyl]-5-benzyl-2-oxopyrrolidin-1-yl]-2-benzyl-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26839 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543