CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8885
Family Name Melatonin receptor type 1B and Melatonin receptor type 1A ligand AGN-PC-00FDVL family
No. of Seeds 1 No. of Other Members 28
Family Centroid CFAMM00074474 Functional Category Bioactive with Natural Product
Superfamily Acetylcholinesterase Inhibitor Rivastigmine Superfamily
Class Class 120

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Opioid receptor ligand opiate Levorphanol Family 18 537
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Zucapsacin family 7 177
Cholesteryl ester transfer protein Inhibitor Anacetrapib Family 3 63
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Substance-P receptor Ligand Ezlopitant Family 10 207
D(3) dopamine receptor Ligand U-99194A Family 7 33
Ivabradine family 1 11
Dapoxetine family 3 40
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Peptide deformylase, mitochondrial Inhibitor Tylophorinidine F... 7 1
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Histamine H3 receptor Ligand A-349821 Family 49 228
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Mu-type opioid receptor Ligand Cyprodime Family 12 8
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Histamine H1 receptor and Arachidonate 5-lipoxygenase Ligand N... 5 6
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
D(3) dopamine receptor ligand S 14297 family 1 2
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Type-2 angiotensin II receptor ligand SureCN244657 family 7 11
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 12 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Sigma non-opioid intracellular receptor 1 ligand BAS 04057753 ... 5 8
Substance-P receptor ligand 3-[bis(4-fluorophenyl)methyl]-1-[(... 5 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 6 1
Carbonic anhydrase 14 and Carbonic anhydrase 9 inhibitor 1-(4-... 2 3
Carbonic anhydrase 14 and Carbonic anhydrase 9 inhibitor 6-met... 2 6
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-(4-methoxyphenox... 2 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 7 1
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
Histamine H3 receptor ligand SureCN6071181 family 2 1
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Dipeptidyl peptidase 4 inhibitor SureCN8267584 family 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26
Transporter and Sodium-dependent serotonin transporter inhibit... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
Motilin receptor and Growth hormone secretagogue receptor type... 1 2
Histamine H3 receptor and Histamine H1 receptor ligand AGN-PC-... 1 0
Kappa-type opioid receptor ligand N-[(1S)-2-[(3S)-3-hydroxypyr... 2 0
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Prostaglandin E synthase inhibitor AGN-PC-09QKN6 family 1 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Orexin receptor type 2 and Orexin receptor type 1 ligand 2-ben... 1 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 2 0
Arachidonate 5-lipoxygenase inhibitor AGN-PC-000I3M family 2 6
Arachidonate 5-lipoxygenase inhibitor AGN-PC-074BAX family 1 0
Putative NP ZINC04061066 Family 18 0
Putative NP ZINC38201335 Family 8 0
NP N-(4-chlorobenzyl)-n-(3-(4-isopropoxyphenyl)-3-phenylpropyl... 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27746 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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