CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8891
Family Name Gonadotropin-releasing hormone receptor ligand 3-[(2R)-2-amino-2-phenylethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-(5-methylthiophen-2-yl)pyrimidine-2,4-dione family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00391456 Functional Category Bioactive
Superfamily Inositol monophosphatase 1 and Menin Binder Superfamily 3
Class Class 3102

Cousin Family NamesSeedsMembers
Alpha-1A adrenergic receptor Ligand SNAP-6201 Family 41 94
Substance-K receptor ligand N-[1-[[(2S)-5-[4-(dimethylsulfamoy... 9 16
Sigma non-opioid intracellular receptor 1 ligand ST50280143 fa... 3 54
Neutrophil elastase inhibitor SureCN7423499 family 5 1
Dipeptidyl peptidase 4 inhibitor SureCN389715 family 2 2
Gonadotropin-releasing hormone receptor ligand 3-[(2R)-2-amino... 9 21
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 9 7
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 7 8
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 6 6
Glucocorticoid receptor ligand 5-[(3-methylphenyl)methyl]-6-(4... 4 5
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 20 2
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 2 0
Calpain-1 catalytic subunit and Cathepsin B inhibitor N-(4-ami... 1 0


External ID

Functional Category

Molecule Name

CFAMM00391457 CHEMBL363759 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-5-(5-chlorothiophen-2-yl)-1-[(2,6-difluorophenyl)methyl]-6-methylpyrimidine-2,4-dione
CFAMM00391456 CHEMBL365012 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-(5-methylthiophen-2-yl)pyrimidine-2,4-dione
CFAMM00391454 CHEMBL186563 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-thiophen-2-ylpyrimidine-2,4-dione

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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