CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8895
Family Name Melanin-concentrating hormone receptor 1 ligand (3S)-3-[[5-(4-ethylphenyl)thiophene-2-carbonyl]-methylamino]-N-methyl-N-[(3R)-1-methylpyrrolidin-3-yl]pyrrolidine-1-carboxamide family
No. of Seeds 15 No. of Other Members 16
Family Centroid CFAMM00391524 Functional Category Bioactive
Superfamily Melanin-concentrating hormone receptor 1 Binder Superfamily 4
Class Class 3814

Cousin Family NamesSeedsMembers
DNA Binder Procarbazine Family 8 358
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-5-[4-(oxan-4-... 21 7
Substance-K receptor ligand N-[1-[[(2S)-5-[4-(dimethylsulfamoy... 9 16
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Growth hormone secretagogue receptor type 1 ligand SureCN76469... 4 4
Sigma non-opioid intracellular receptor 1 ligand ST50280143 fa... 3 54
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 9 7
Melanin-concentrating hormone receptor 1 ligand (3S)-3-[[5-[4-... 1 1
Melanin-concentrating hormone receptor 1 ligand (3S)-3-[[5-(2-... 5 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075C6K ... 3 22
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 6 6
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Melanin-concentrating hormone receptor 1 ligand N-methyl-4-(4-... 1 0
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 1 0
Melanin-concentrating hormone receptor 1 ligand (3S)-3-[6-(4-c... 13 9
Coagulation factor X inhibitor 5-chloro-N-[(1R,2S)-2-[[4-[1-(p... 2 0
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
Kappa-type opioid receptor ligand 2-[2-oxo-2-[(2S)-2-(pyrrolid... 2 1
Capsid scaffolding protein inhibitor AC1LAC4T family 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 5
Calpain-1 catalytic subunit and Cathepsin B inhibitor N-(4-ami... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00391512 CHEMBL214513 Bioactive N-[(3S)-1-[(3R)-3-[(4,4-dimethylcyclohexyl)amino]pyrrolidine-1-carbonyl]pyrrolidin-3-yl]-5-(4-ethylphenyl)-N-methylthiophene-2-carboxamide
CFAMM00391525 CHEMBL265255 Bioactive N-[(3S)-1-[(3R)-3-(cyclopentylamino)pyrrolidine-1-carbonyl]pyrrolidin-3-yl]-5-(4-ethylphenyl)-N-methylthiophene-2-carboxamide
CFAMM00391518 CHEMBL607121 Bioactive (3S)-N-[(3R)-1-(4,4-dimethylcyclohexyl)pyrrolidin-3-yl]-N-methyl-3-[methyl-[5-[4-(trifluoromethyl)phenyl]thiophene-2-carbonyl]amino]pyrrolidine-1-carboxamide
CFAMM00391524 CHEMBL186827 Bioactive (3S)-3-[[5-(4-ethylphenyl)thiophene-2-carbonyl]-methylamino]-N-methyl-N-[(3R)-1-methylpyrrolidin-3-yl]pyrrolidine-1-carboxamide
CFAMM00391530 CHEMBL188654 Bioactive (3S)-N-methyl-N-[(3R)-1-methylpyrrolidin-3-yl]-3-[methyl-[5-[4-(trifluoromethyl)phenyl]thiophene-2-carbonyl]amino]pyrrolidine-1-carboxamide
CFAMM00391510 CHEMBL363470 Bioactive (3S)-N-methyl-3-[methyl-[5-(4-methylphenyl)thiophene-2-carbonyl]amino]-N-[(3R)-1-methylpyrrolidin-3-yl]pyrrolidine-1-carboxamide
CFAMM00391523 CHEMBL267797 Bioactive N-[(3S)-1-[(3R)-3-(dimethylamino)pyrrolidine-1-carbonyl]pyrrolidin-3-yl]-5-(4-ethylphenyl)-N-methylthiophene-2-carboxamide
CFAMM00391516 CHEMBL217300 Bioactive 5-(4-ethylphenyl)-N-methyl-N-[(3S)-1-[(3R)-3-(oxan-4-ylamino)pyrrolidine-1-carbonyl]pyrrolidin-3-yl]thiophene-2-carboxamide
CFAMM00391509 CHEMBL214497 Bioactive 5-(4-ethylphenyl)-N-methyl-N-[(3S)-1-[(3R)-3-[methyl(oxan-4-yl)amino]pyrrolidine-1-carbonyl]pyrrolidin-3-yl]thiophene-2-carboxamide
CFAMM00391528 CHEMBL189190 Bioactive (3S)-N-methyl-3-[methyl-[5-(4-propan-2-ylphenyl)thiophene-2-carbonyl]amino]-N-[(3R)-1-methylpyrrolidin-3-yl]pyrrolidine-1-carboxamide
CFAMM00391508 CHEMBL215446 Bioactive 5-(4-ethylphenyl)-N-methyl-N-[(3S)-1-[(3R)-3-(methylamino)pyrrolidine-1-carbonyl]pyrrolidin-3-yl]thiophene-2-carboxamide
CFAMM00391521 CHEMBL442064 Bioactive N-[(3S)-1-[(3R)-3-[(4,4-dimethylcyclohexyl)amino]pyrrolidine-1-carbonyl]pyrrolidin-3-yl]-N-methyl-5-(4-methylphenyl)thiophene-2-carboxamide
CFAMM00391527 CHEMBL215308 Bioactive 5-(4-ethylphenyl)-N-methyl-N-[(3S)-1-[(3R)-3-(oxan-4-ylmethylamino)pyrrolidine-1-carbonyl]pyrrolidin-3-yl]thiophene-2-carboxamide
CFAMM00391507 CHEMBL365443 Bioactive (3S)-3-[[5-(2,4-dimethylphenyl)thiophene-2-carbonyl]-methylamino]-N-methyl-N-[(3R)-1-methylpyrrolidin-3-yl]pyrrolidine-1-carboxamide
CFAMM00391526 CHEMBL215067 Bioactive N-[(3S)-1-[(3R)-3-[(4,4-dimethylcyclohexyl)amino]pyrrolidine-1-carbonyl]pyrrolidin-3-yl]-N-methyl-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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