CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8918
Family Name Amine oxidase [flavin-containing] A and Amine oxidase [flavin-containing] B inhibitor AGN-PC-004MHX family
No. of Seeds 3 No. of Other Members 12
Family Centroid CFAMM00391623 Functional Category Bioactive with Human Metabolite & Natural Product
Superfamily X-box-binding protein 1 and Ras-related protein Rab-9A Binder Superfamily
Class Class 1491

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Cyclooxygenase Inhibitor Ketorolac Family 3 40
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Substance-P receptor Ligand TAK-637 Family 18 63
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Integrase Inhibitor L-731,988 Family 1 4
Dual specificity mitogen-activated protein kinase kinase 1 Inh... 2 7
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
MO15-related protein kinase Pfmrk Inhibitor (e)-1-(4-nitro-phe... 2 9
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Cannabinoid receptor 2 Ligand JWH-249 Family 7 13
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
M-phase inducer phosphatase 2 Inhibitor 6,7-dibromoquinoline-5... 1 2
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Translocator protein Inhibitor 5-phenyl-6-thia-10b-aza-benzo[e... 2 3
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Aldose reductase Inhibitor 3-(3-benzoyl-1h-pyrrol-1-yl)propano... 3 7
Platelet-activating factor receptor ligand A-85783 family 13 62
Progesterone receptor and Androgen receptor ligand AGN-PC-04V9... 2 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 6
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Translocator protein inhibitor AGN-PC-08WI0V family 1 0
Histamine H3 receptor ligand SureCN1857507 family 1 4
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
Serine/threonine-protein kinase PLK1 and MAP kinase-activated ... 1 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Melanin-concentrating hormone receptor 1 ligand N-[(3S)-1-[[(3... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
D(3) dopamine receptor and D(2) dopamine receptor ligand (7S)-... 2 19
72 kDa type IV collagenase and Interstitial collagenase inhibi... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
Tyrosyl-DNA phosphodiesterase 1 and Huntingtin inhibitor CHEMB... 1 8
Histone deacetylase 6 and Histone deacetylase 8 inhibitor N-hy... 1 0
Metabotropic glutamate receptor 5 ligand 3-methyl-1-[2-[3-(tri... 3 1
Prostaglandin E synthase inhibitor 3-(4-dodecanoyl-1,5-dimethy... 2 0
Arachidonate 5-lipoxygenase inhibitor 1-[1-(4-methylphenyl)sul... 1 0
Histone deacetylase 1 and HD2 type histone deacetylase HDA106 ... 1 2
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 1
Naphthyridines Metabolite 3-Acetyl-2,7-naphthyridine Family 1 4
Pyrrolizines Metabolite 2,3-Dihydro-5-methyl-1H-pyrrolizine-7-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00391617 CHEMBL372923 Bioactive (2R)-1-(1-methylpyrrol-2-yl)-2-phenyl-2-pyrrolidin-1-ylethanone
CFAMM00391623 CHEMBL187462 Bioactive AGN-PC-004MHX
CFAMM00391632 CHEMBL191203 Bioactive (2S)-1-(1-methylpyrrol-2-yl)-2-phenyl-2-pyrrolidin-1-ylethanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27272 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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