CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM893
Family Name Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)-N-hydroxy-6-(2-methylpropyl)-3-(4-methylsulfonylbenzoyl)-5-oxo-12-oxa-4-azabicyclo[11.2.2]heptadeca-1(15),13,16-triene-7-carboxamide family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00232171 Functional Category Bioactive
Superfamily 72 kDa type IV collagenase and Growth hormone secretagogue receptor type 1 Binder Superfamily
Class Class 3079

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
HIV-1 protease Inhibitor Lopinavir Family 4 25
Renin Inhibitor Aliskiren Family 28 107
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Matrix metalloproteinase-9 and Collagenase 3 Inhibitor 4-amino... 1 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Caspase-1 inhibitor 5-(3-carbamoylnaphthalen-2-yl)oxy-3-[[(2S)... 1 11
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 4 10
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-2-... 4 6
Pol polyprotein inhibitor MDL 74538 family 11 1
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 0
Caspase-1 inhibitor (3S)-3-[2-[3-(naphthalene-1-carbonylamino)... 13 5
Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Diox... 7 6
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 5 2
Follicle-stimulating hormone receptor ligand SureCN6140614 family 2 8
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Stromelysin-1 and Interstitial collagenase inhibitor (2R)-2-[4... 4 1
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Growth hormone secretagogue receptor type 1 ligand SureCN76477... 2 1
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
72 kDa type IV collagenase and Interstitial collagenase inhibi... 2 0
Stromelysin-1 inhibitor (2R)-2-[[(2S)-1-[(6S)-6-(methylcarbamo... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00316969 CHEMBL325940 Bioactive (3S,6R,7S)-N-hydroxy-3-[4-(hydroxymethyl)benzoyl]-6-(2-methylpropyl)-5-oxo-12-oxa-4-azabicyclo[11.2.2]heptadeca-1(15),13,16-triene-7-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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