CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8931
Family Name Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha and Protein farnesyltransferase subunit beta inhibitor AGN-PC-075FY6 family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00391695 Functional Category Bioactive
Superfamily Protein farnesyltransferase subunit beta Inhibitor A-313326 Superfamily
Class Class 2754

Cousin Family NamesSeedsMembers
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Aromatase Inhibitor 3-((1h-imidazol-1-yl)methyl)-9h-xanthen-9-... 6 17
Aromatase Inhibitor 1-(7-methoxy-2-phenyl-chroman-4-yl)-1h-imi... 2 22
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 1-... 2 9
Aromatase Inhibitor 4-((1h-imidazol-1-yl)methyl)-2h-chromen-2-... 3 69
Cytochrome P450 3A4 Inhibitor SK&F-96365 Family 2 26
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor Rac-4'-(1-i... 5 9
Aromatase Inhibitor 1-(4-nitro-2-phenoxybenzyl)-1h-imidazole F... 1 4
Protein farnesyltransferase subunit beta Inhibitor A-313326 Fa... 85 149
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 14 0
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-07YOWS family 4 6
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 19 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 8 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 21 0
Aromatase inhibitor AGN-PC-075MOK family 1 4
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 8 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 3-[2... 2 25
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cytochrome P450 26A1 and Cytochrome P450 3A4 inhibitor 3-[6-[(... 14 26
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 3
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Aromatase inhibitor 4-[(Z)-1-(3,5-dimethoxyphenyl)-3-imidazol-... 1 2
Delta-type opioid receptor and Kappa-type opioid receptor liga... 2 0
Alpha-1A adrenergic receptor ligand AGN-PC-0793UT family 3 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00391695 CHEMBL426063 Bioactive AGN-PC-075FY6

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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