CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8942
Family Name Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00292781 Functional Category Bioactive
Superfamily D(4) dopamine receptor and D(2) dopamine receptor Binder Superfamily
Class Class 3054

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
AP26113 family 16 90
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
RAC-gamma serine/threonine-protein kinase Inhibitor GSK690693 ... 16 27
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Cyclin-dependent kinase 2 Inhibitor 6-cyclohexylmethyloxy-2-(4... 2 11
Cyclin-dependent kinase 2 Inhibitor 2-anilino-6-cyclohexylmeth... 4 13
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Platelet-derived growth factor receptor alpha and Platelet-der... 3 18
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 9 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 2 0
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 5 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 2
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 16 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Dual specificity protein kinase TTK inhibitor 2-[1-[4-[[6-(cyc... 8 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Rho-associated protein kinase 1 inhibitor SureCN4716133 family 2 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Motilin receptor ligand SureCN2012437 family 4 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
5-hydroxytryptamine receptor 1A and Gonadotropin-releasing hor... 3 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26413 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543