CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8949
Family Name Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-00EUA4 family
No. of Seeds 7 No. of Other Members 1
Family Centroid CFAMM00391888 Functional Category Bioactive
Superfamily Neuronal acetylcholine receptor subunit alpha-7 and Cholinesterase Binder Superfamily
Class Class 2536

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Integrin beta-3 Inhibitor L-739758 Family 2 4
Cathepsin B and Cathepsin K Inhibitor L-006235-1 Family 19 75
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
D(4) dopamine receptor Ligand ABT-670 Family 4 14
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(2... 2 20
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Deoxycytidine kinase inhibitor N-[(1S,3S)-3-(4-amino-5-fluoro-... 2 5
Pyruvate kinase PKLR and Pyruvate kinase PKM inhibitor AGN-PC-... 17 23
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4... 4 0
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1367658 ... 1 7
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Sonic hedgehog protein inhibitor 3-chloro-N-[4-(methylamino)cy... 2 3
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1231206 ... 6 7
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Glycogen phosphorylase, liver form inhibitor 2,3-dichloro-N-[(... 2 14
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-073U... 3 8
Platelet-activating factor receptor ligand YM-461 family 1 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 13
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenyl... 3 5
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Histamine H3 receptor ligand SureCN1857507 family 1 4
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 4 10
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 2
Glycogen synthase kinase-3 beta inhibitor 7-(6-chloropyridin-2... 2 3
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Serine/threonine-protein kinase Chk1 inhibitor 2-(1H-indol-5-y... 2 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[acetyl(thio... 6 3
C-C chemokine receptor type 5 ligand 6-chloro-2,4-dimethyl-N-[... 1 0
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Histone deacetylase 1 inhibitor N-hydroxy-5-[1-[2-[(1-methylin... 4 1
Histone deacetylase 1 inhibitor 5-[5-[[(2-chlorophenyl)methyla... 4 1
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 4 4
Metabotropic glutamate receptor 1 ligand SureCN8238697 family 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 4 4
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
Coagulation factor X inhibitor SureCN1253902 family 2 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 2
Metabotropic glutamate receptor 5 ligand N-[(2R)-3-hydroxy-3-m... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00391888 CHEMBL188469 Bioactive AGN-PC-00EUA4
CFAMM00391887 CHEMBL210865 Bioactive SureCN5704812
CFAMM00391893 CHEMBL268939 Bioactive SureCN5704836
CFAMM00391892 CHEMBL364069 Bioactive SureCN4206213
CFAMM00391891 CHEMBL403857 Bioactive N-[(3R,5R)-1-azabicyclo[3.2.1]octan-3-yl]thieno[3,2-c]pyridine-6-carboxamide
CFAMM00391889 CHEMBL365992 Bioactive 5-pyridin-2-yl-N-[(2R,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]thiophene-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26412 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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