CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8958
Family Name Sodium-dependent serotonin transporter and 5-hydroxytryptamine receptor 1A ligand 3-[4-[4-(1,3-benzodioxol-5-yl)piperazin-1-yl]butyl]-1H-indole-5-carbonitrile family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00391942 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin transporter Binder Superfamily 3
Class Class 3208

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Sigma non-opioid intracellular receptor 1 and Kappa-type opioi... 3 12
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Dual specificity mitogen-activated protein kinase kinase 1 inh... 5 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Cannabinoid receptor 1 ligand AGN-PC-088XYA family 4 6
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 7 4
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Glucocorticoid receptor ligand SureCN4194063 family 1 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Sodium-dependent serotonin transporter and D(2) dopamine recep... 3 0
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Mast/stem cell growth factor receptor Kit and Serine/threonine... 1 0
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
5-hydroxytryptamine receptor 6 ligand AGN-PC-075BWR family 1 1
Gastrin/cholecystokinin type B receptor and Tyrosyl-DNA phosph... 2 10
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Protein kinase C theta type and Protein kinase C delta type in... 10 7
5-hydroxytryptamine receptor 4 ligand 4-amino-5-chloro-N-[1-[8... 2 2
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
Transient receptor potential cation channel subfamily V member... 3 2
Vascular endothelial growth factor receptor 2 ligand (4Z)-4-[(... 3 0
Melanin-concentrating hormone receptor 1 ligand 6-[3-methoxy-4... 5 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00391942 CHEMBL188799 Bioactive 3-[4-[4-(1,3-benzodioxol-5-yl)piperazin-1-yl]butyl]-1H-indole-5-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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