CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8965
Family Name Melanin-concentrating hormone receptor 1 ligand AGN-PC-075C6K family
No. of Seeds 3 No. of Other Members 22
Family Centroid CFAMM00391982 Functional Category Bioactive
Superfamily Disintegrin and Deoxycytidine kinase Binder Superfamily
Class Class 3129

Cousin Family NamesSeedsMembers
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
DNA Binder Procarbazine Family 8 358
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Neuromedin-K receptor Ligand Osanetant Family 38 192
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 2 23
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Disintegrin and metalloproteinase domain-containing protein 17... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
C-C chemokine receptor type 5 ligand N-[(1S)-3-[(3aS,6aR)-5-(2... 1 1
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Melanin-concentrating hormone receptor 1 ligand (3S)-3-[[5-(4-... 15 16
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 3
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Melanin-concentrating hormone receptor 1 ligand N-methyl-4-(4-... 1 0
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 1
5-hydroxytryptamine receptor 1A and Alpha-2B adrenergic recept... 2 2
Sodium-dependent dopamine transporter and Transporter inhibito... 6 0
Prothrombin inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethyl... 8 1
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 2,6-d... 1 1
Reverse transcriptase/RNaseH inhibitor (R)-(+)9B-(3-METHYL)PHE... 5 24


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00391976 CHEMBL189043 Bioactive (3S)-3-[[4-(4-chlorophenyl)benzoyl]-methylamino]-N-methyl-N-[(3R)-1-methylpyrrolidin-3-yl]pyrrolidine-1-carboxamide
CFAMM00391982 CHEMBL360976 Bioactive AGN-PC-075C6K
CFAMM00391977 CHEMBL217528 Bioactive 4-(4-chlorophenyl)-N-methyl-N-[(3S)-1-[(3S)-3-(3-phenylpropylamino)pyrrolidine-1-carbonyl]pyrrolidin-3-yl]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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