CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8972
Family Name Gonadotropin-releasing hormone receptor and Cytochrome P450 3A4 ligand 3-[(2R)-2-amino-2-phenylethyl]-5-(2-chlorophenyl)-1-[(2,6-difluorophenyl)methyl]pyrimidine-2,4-dione family
No. of Seeds 7 No. of Other Members 8
Family Centroid CFAMM00387127 Functional Category Bioactive
Superfamily Cytochrome P450 3A4 and Gonadotropin-releasing hormone receptor Binder Superfamily
Class Class 3510

Cousin Family NamesSeedsMembers
Alpha-1A adrenergic receptor Ligand SNAP-6201 Family 41 94
Neutrophil elastase inhibitor SureCN7423499 family 5 1
Dipeptidyl peptidase 4 inhibitor SureCN389715 family 2 2
Gonadotropin-releasing hormone receptor ligand 3-[(2R)-2-amino... 9 21
Gonadotropin-releasing hormone receptor ligand 3-[(2R)-2-amino... 3 1
Glucocorticoid receptor ligand 5-[(3-methylphenyl)methyl]-6-(4... 4 5
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 20 2
Substance-P receptor ligand SureCN8936495 family 1 0
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 2 0
Peptidyl-prolyl cis-trans isomerase A inhibitor AGN-PC-073EZA ... 2 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00392032 CHEMBL360143 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-1-[(2-chloro-6-fluorophenyl)methyl]-5-(2-fluorophenyl)-6-methylpyrimidine-2,4-dione
CFAMM00392037 CHEMBL426783 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-5-(2-chlorophenyl)-1-[(2,6-difluorophenyl)methyl]-6-methylpyrimidine-2,4-dione
CFAMM00392035 CHEMBL75347 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-1-[(2-chloro-6-fluorophenyl)methyl]-5-(2-fluorophenyl)-6-methylpyrimidine-2,4-dione;2,2,2-trifluoroacetic acid
CFAMM00392028 CHEMBL365561 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-5-(2-chloro-4-methylphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]pyrimidine-2,4-dione
CFAMM00392027 CHEMBL450471 Bioactive SureCN1378898

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45277 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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