CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8977
Family Name Reverse transcriptase/RNaseH and Cytochrome P450 2C19 inhibitor AC1MHVAD family
No. of Seeds 7 No. of Other Members 2
Family Centroid CFAMM00392056 Functional Category Bioactive
Superfamily Smoothened homolog Inhibitor LDE225 Superfamily
Class Class 1163

Cousin Family NamesSeedsMembers
Smoothened homolog Inhibitor LDE225 Family 3 76
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Reverse transcriptase/RNaseH inhibitor Dipyridodiazepinone der... 1 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Growth hormone secretagogue receptor type 1 and Potassium volt... 2 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Motilin receptor ligand SureCN2765637 family 1 1
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Histamine H3 receptor ligand AGN-PC-03Z8HB family 3 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 3 5
Diacylglycerol O-acyltransferase 1 inhibitor 3-[[1-[5-[(3-meth... 1 1
Diacylglycerol O-acyltransferase 1 inhibitor 2-[[4-[5-[(3-meth... 2 6


External ID

Functional Category

Molecule Name

CFAMM00392056 CHEMBL192530 Bioactive AC1MHVAD
CFAMM00392055 CHEMBL189423 Bioactive AC1MHVAS
CFAMM00392054 CHEMBL191163 Bioactive AC1MHVAP
CFAMM00392060 CHEMBL189928 Bioactive 3-ethyl-4-[2-(11-ethyl-5-methyl-6-oxodipyrido[2,3-d:2',3'-h][1,4]diazepin-8-yl)ethoxy]benzoic acid
CFAMM00392053 CHEMBL366017 Bioactive AC1MHVAM
CFAMM00392059 CHEMBL192790 Bioactive 3-bromo-4-[2-(11-ethyl-5-methyl-6-oxodipyrido[2,3-d:2',3'-h][1,4]diazepin-8-yl)ethoxy]benzoic acid
CFAMM00392058 CHEMBL189942 Bioactive AC1MHVAV

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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