CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8979
Family Name D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand 6-(4-chlorophenyl)-3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione family
No. of Seeds 3 No. of Other Members 4
Family Centroid CFAMM00392066 Functional Category Bioactive
Superfamily Envelope glycoprotein gp120 Inhibitor BMS-488043 Superfamily
Class Class 1163

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Alpha-1A adrenergic receptor Ligand A-131701 Family 16 17
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Cannabinoid receptor 1 ligand NIDA-41020 family 7 5
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 3-... 4 8
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 7 15
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
Cannabinoid receptor 1 ligand AGN-PC-0766FR family 4 3
Peroxisome proliferator-activated receptor delta and Peroxisom... 7 5
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
D(2) dopamine receptor ligand SureCN10575660 family 1 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... 6 15
Adenosine receptor A2b and Adenosine receptor A2a ligand SureC... 2 0
Adenosine receptor A3 and Adenosine receptor A2a ligand 9-prop... 1 0
Neuromedin-K receptor ligand [3-(4-chlorophenyl)-1H-pyrazol-5-... 3 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00392062 CHEMBL2113056 Bioactive 3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-6-(4-methoxyphenyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione
CFAMM00392066 CHEMBL189437 Bioactive 6-(4-chlorophenyl)-3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27263 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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