CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8989
Family Name S-methyl-5'-thioadenosine phosphorylase inhibitor 1-[(4-amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(propan-2-ylsulfanylmethyl)pyrrolidin-3-ol family
No. of Seeds 7 No. of Other Members 1
Family Centroid CFAMM00392124 Functional Category Bioactive
Superfamily S-methyl-5'-thioadenosine phosphorylase and 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Binder Superfamily
Class Class 3353

Cousin Family NamesSeedsMembers
Purine nucleoside phosphorylase Inhibitor Forodesine Family 11 54
Adenosine receptor A1 Ligand SLV320 Family 6 79
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inh... 17 17
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inh... 7 6
S-methyl-5'-thioadenosine phosphorylase inhibitor SureCN997478... 8 0
S-methyl-5'-thioadenosine phosphorylase inhibitor 2-[[(4-amino... 5 0
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0


External ID

Functional Category

Molecule Name

CFAMM00392127 CHEMBL189837 Bioactive AGN-PC-075I7G
CFAMM00392126 CHEMBL190867 Bioactive AGN-PC-075I6P
CFAMM00392125 CHEMBL425188 Bioactive AGN-PC-075I8U
CFAMM00392124 CHEMBL191281 Bioactive 1-[(4-amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(propan-2-ylsulfanylmethyl)pyrrolidin-3-ol
CFAMM00392123 CHEMBL191544 Bioactive AGN-PC-075I6V
CFAMM00392122 CHEMBL365378 Bioactive 1-[(4-amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(butylsulfanylmethyl)pyrrolidin-3-ol
CFAMM00392128 CHEMBL189911 Bioactive AGN-PC-075I6C

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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