CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8999
Family Name NS5B protein inhibitor AC1O5AET family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00392176 Functional Category Bioactive
Superfamily Phospholipase A2, membrane associated and Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J33) Binder Superfamily
Class Class 297

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Integrin beta-3 Inhibitor L-756568 Family 8 59
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Lethal factor Inhibitor 3-(2,5-dimethyl-1h-pyrrol-1-yl)benzoic... 2 44
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family 3 20
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Neuromedin-K receptor and Substance-K receptor ligand 2-[2-phe... 2 2
Cannabinoid receptor 1 and 5-hydroxytryptamine receptor 1A lig... 2 12
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 11
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
NS5B protein inhibitor AC1NQMYG family 6 12
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4R,... 3 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Renin inhibitor SureCN1144364 family 3 15
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 17 4
Prostaglandin D2 receptor 2 ligand SureCN2189431 family 7 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 5
NS5B protein inhibitor AGN-PC-00A17Z family 1 23
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 5 12
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
Prostaglandin D2 receptor and Prostaglandin E2 receptor EP2 su... 2 0
NS5B protein inhibitor AC1NQMYP family 5 0
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 ligand 4-[2-[4-[[(1-propan-2-yl... 1 1
Cannabinoid receptor 1 ligand AGN-PC-0766FR family 4 3
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
C-C chemokine receptor type 5 ligand N-methyl-4-[6-methyl-5-[[... 2 2
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Prothrombin inhibitor AGN-PC-074I2Z family 2 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Potassium voltage-gated channel subfamily A member 5 ligand AG... 1 0
NS5B protein inhibitor AGN-PC-0765HJ family 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00392176 CHEMBL190428 Bioactive AC1O5AET
CFAMM00392175 CHEMBL190098 Bioactive AC1O5AEW
CFAMM00392174 CHEMBL362957 Bioactive AC1O5AF2

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27513 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543