CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9004
Family Name Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ligand 3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-6-phenyl-1,7-dihydropyrrolo[2,3-d]pyrimidine-2,4-dione family
No. of Seeds 7 No. of Other Members 12
Family Centroid CFAMM00327466 Functional Category Bioactive with Natural Product
Superfamily Cannabinoid receptor 2 and Cannabinoid receptor 1 Binder Superfamily
Class Class 824

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 2
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 1 0
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Translocator protein inhibitor N-(4-chlorophenyl)-N-methyl-2-(... 2 0
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-... 2 14
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 6 6
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 7 15
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 2 0
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 2 1
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Motilin receptor ligand SureCN2768052 family 3 0
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
Prostaglandin E synthase inhibitor 2-(2-chloro-6-fluorophenyl)... 9 1
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 4 11
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 8
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... 6 15
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor SureCN3553433 family 22 0
Receptor-interacting serine/threonine-protein kinase 1 ligand ... 1 11


CFAM Mol ID

External ID

Functional Category

Molecule Name
CFAMM00392270 CHEMBL199876 Bioactive 6-(4-chlorophenyl)-3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-1,7-dihydropyrrolo[2,3-d]pyrimidine-2,4-dione
CFAMM00392246 CHEMBL57163 Bioactive SureCN12648691
CFAMM00392258 CHEMBL443567 Bioactive 6-(2-chlorophenyl)-3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-1,7-dihydropyrrolo[2,3-d]pyrimidine-2,4-dione
CFAMM00392251 CHEMBL200802 Bioactive 3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-6-(2-methylphenyl)-1,7-dihydropyrrolo[2,3-d]pyrimidine-2,4-dione

Statistics of CFAM Database
 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48694 visits since 2014 .........

 


Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 
Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543