CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9013
Family Name Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluorophenyl)-2-methyl-1H-imidazol-4-yl]-1-propan-2-ylsulfonylbenzimidazol-2-amine;methanesulfonic acid family
No. of Seeds 9 No. of Other Members 3
Family Centroid CFAMM00182926 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 14 and Thrombopoietin receptor Binder Superfamily
Class Class 4688

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
JNJ-39439335 family 5 11
SB989 family 17 91
Tryptase Inhibitor Babim Family 12 90
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... 2 12
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Sterol O-acyltransferase 1 inhibitor 1-(2,4-difluorophenyl)-3-... 8 90
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Neuropeptide Y receptor type 5 ligand 8-[6-(4-fluorophenyl)-1H... 2 1
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperid... 2 8
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Transient receptor potential cation channel subfamily M member... 9 0
Transient receptor potential M8 protein and Cytochrome P450 2C... 4 0
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 3
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Histamine H4 receptor and Histamine H3 receptor ligand (E)-[(3... 4 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Cyclin-dependent kinase 1 inhibitor 4-[[4-(3H-benzimidazol-5-y... 1 0
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... 2 13
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 ligand ... 8 19
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00BSP9 ... 6 12
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 1
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... 2 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206058 family 5 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Orexin receptor type 2 and Orexin receptor type 1 ligand (2S)-... 2 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0
Mitogen-activated protein kinase 14 inhibitor 6-[2-[2-chloro-6... 2 0
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Tyrosine-protein phosphatase non-receptor type 1 ligand sodium... 1 44
Type-1 angiotensin II receptor ligand AGN-PC-04X8EF family 1 1
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Gonadotropin-releasing hormone receptor ligand AGN-PC-00AWCA f... 1 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
5-hydroxytryptamine receptor 2B ligand SureCN1299053 family 1 1
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
Prostaglandin E synthase inhibitor AGN-PC-04SSMB family 6 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family 7 0
Tyrosine-protein phosphatase non-receptor type 1 ligand sodium... 2 6
Acyl-CoA:cholesterol acyltransferase and Sterol O-acyltransfer... 3 2
Tyrosine-protein phosphatase non-receptor type 1 ligand sodium... 1 0
Tyrosine-protein phosphatase non-receptor type 1 and Tyrosine-... 1 15


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00392314 CHEMBL371145 Bioactive SureCN5769207
CFAMM00392306 CHEMBL364925 Bioactive AGN-PC-00FGEJ
CFAMM00392312 CHEMBL190514 Bioactive AGN-PC-005ZO1
CFAMM00392310 CHEMBL191113 Bioactive AGN-PC-004QTG
CFAMM00392307 CHEMBL363831 Bioactive 6-[2-tert-butyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-1-propan-2-ylsulfonylbenzimidazol-2-amine;methanesulfonic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27043 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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