CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9041
Family Name Vascular endothelial growth factor receptor 1 and Vascular endothelial growth factor receptor 3 ligand AGN-PC-007DK6 family
No. of Seeds 11 No. of Other Members 38
Family Centroid CFAMM00392519 Functional Category Bioactive
Superfamily Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-aminobutyric acid receptor subunit gamma-2 Binder Superfamily 5
Class Class 1070

Cousin Family NamesSeedsMembers
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
MK-3328 family 2 32
Adenosine receptor A1 and Adenosine receptor A2a Ligand CGS-15... 24 47
Mitogen-activated protein kinase 14 Inhibitor CP-808844 Family 39 43
Potassium voltage-gated channel subfamily H member 2 and Vascu... 1 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Aurora kinase A and Potassium voltage-gated channel subfamily ... 8 7
Adenosine receptor A2a ligand SureCN6867940 family 13 13
Mitogen-activated protein kinase 14 inhibitor 3mvm family 6 1
Survival motor neuron protein and Neuropeptide S receptor liga... 1 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 5
Adenosine receptor A3 ligand CHEMBL1834703 family 2 1
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Prothrombin inhibitor SureCN6925359 family 6 18
Prothrombin and Coagulation factor X inhibitor SureCN6929748 f... 6 5
Prothrombin and Trypsin-1 inhibitor SureCN6930543 family 10 0
Prothrombin inhibitor SureCN6931925 family 3 0
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
Mitogen-activated protein kinase 14 inhibitor methyl 4-[5-(eth... 3 11
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 6
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Adenosine receptor A2a and Adenosine receptor A1 ligand 5-[(7S... 6 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 3
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 25 5
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 29 1
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Mitogen-activated protein kinase 14 inhibitor ethyl 4-[5-[(3-f... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Adenosine receptor A3 and Adenosine receptor A2a ligand (3R,4S... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 2 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00392516 CHEMBL191913 Bioactive 5-[[6-[5-(cyclopropylmethyl)-1,3,4-oxadiazol-2-yl]-5-propan-2-ylpyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]-2,4-difluoro-N-methoxybenzamide
CFAMM00392502 CHEMBL195398 Bioactive 2,4-difluoro-N-methoxy-5-[[6-[5-(methylsulfonylmethyl)-1,3,4-oxadiazol-2-yl]-5-propan-2-ylpyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]benzamide
CFAMM00392508 CHEMBL370515 Bioactive AGN-PC-008QJ3
CFAMM00392488 CHEMBL365318 Bioactive 2,4-difluoro-N-methoxy-5-[[6-(5-methyl-1,3,4-oxadiazol-2-yl)-5-propan-2-ylpyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]benzamide
CFAMM00392513 CHEMBL195847 Bioactive 5-[[6-[5-(dimethylamino)-1,3,4-oxadiazol-2-yl]-5-propan-2-ylpyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]-2,4-difluoro-N-methoxybenzamide
CFAMM00392506 CHEMBL371373 Bioactive AGN-PC-007TV9
CFAMM00392519 CHEMBL192101 Bioactive AGN-PC-007DK6
CFAMM00392525 CHEMBL190980 Bioactive AGN-PC-009NQV
CFAMM00392524 CHEMBL271864 Bioactive 5-[[6-[5-(4-aminopiperidin-1-yl)-1,3,4-oxadiazol-2-yl]-5-propan-2-ylpyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]-N-cyclopropyl-2,4-difluorobenzamide
CFAMM00392491 CHEMBL373365 Bioactive 2,4-difluoro-N-methoxy-5-[[5-propan-2-yl-6-(5-propan-2-yl-1,3,4-oxadiazol-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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