CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9043
Family Name Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family
No. of Seeds 6 No. of Other Members 3
Family Centroid CFAMM00392546 Functional Category Bioactive
Superfamily Metabotropic glutamate receptor 5 and Sodium channel protein type 1 subunit alpha Binder Superfamily
Class Class 2568

Cousin Family NamesSeedsMembers
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 F... 11 20
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Metabotropic glutamate receptor 5 Ligand 2-methyl-7-m-tolyl-1,... 5 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Metabotropic glutamate receptor 5 Ligand 5-(2-(3-chlorophenyl)... 2 13
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Prostaglandin D2 receptor ligand N-[2-(2,4-dichlorophenyl)ethy... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Corticotropin-releasing factor receptor 1 ligand 5-(2,4-dichlo... 5 17
Vascular endothelial growth factor receptor 2 and Fibroblast g... 5 2
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 14 14
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Dihydrofolate reductase inhibitor 5-[4-[(3,4-dichlorophenyl)me... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 0
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 1 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 2 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 14
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 1 1
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-07... 1 1
1-acyl-sn-glycerol-3-phosphate acyltransferase beta inhibitor ... 3 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 4-N-[... 16 21


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00392542 CHEMBL35116 Bioactive Aminomethylpyrimidine 1cb
CFAMM00392547 CHEMBL324777 Bioactive SureCN1834266
CFAMM00392539 CHEMBL37960 Bioactive Aminomethylpyrimidine 1d
CFAMM00392546 CHEMBL34842 Bioactive Aminomethylpyrimidine 1ck
CFAMM00392545 CHEMBL36666 Bioactive Aminomethylpyrimidine 1cj
CFAMM00392544 CHEMBL1909975 Bioactive 5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-difluorophenyl)pyrimidin-4-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26236 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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