CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9044
Family Name Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)-2-methyl-7H-pyrrolo[3,4-b]pyridin-5-one family
No. of Seeds 4 No. of Other Members 8
Family Centroid CFAMM00392064 Functional Category Bioactive
Superfamily Nociceptin receptor and Mu-type opioid receptor Binder Superfamily 6
Class Class 1652

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Arachidonate 5-lipoxygenase Inhibitor MK-591 Family 9 161
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 3 4
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Sonic hedgehog protein inhibitor 3-methoxy-1-methyl-4-oxo-5-ph... 5 3
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
Cannabinoid receptor 1 ligand AGN-PC-0766FR family 4 3
Peroxisome proliferator-activated receptor delta and Peroxisom... 7 5
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
D(2) dopamine receptor ligand SureCN10575660 family 1 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
Vasopressin V2 receptor ligand SureCN4400636 family 1 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Prostaglandin E2 receptor EP1 subtype ligand 1-[[5-chloro-2-(2... 9 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 18000... 1 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Neuromedin-K receptor ligand [3-(4-chlorophenyl)-1H-pyrazol-5-... 3 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00392556 CHEMBL1909991 Bioactive 3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)-2-methyl-5H-pyrrolo[3,4-b]pyridin-7-one
CFAMM00392549 CHEMBL459807 Bioactive SureCN294346
CFAMM00392553 CHEMBL2441829 Bioactive 3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(4-methoxyphenyl)-2-methyl-7H-pyrrolo[3,4-b]pyridin-5-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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