CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9047
Family Name Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-6-(1-methylpyrazol-3-yl)-7H-pyrrolo[3,4-b]pyridin-5-one family
No. of Seeds 3 No. of Other Members 6
Family Centroid CFAMM00392574 Functional Category Bioactive
Superfamily Cannabinoid receptor 1 and Dipeptidyl peptidase 9 Binder Superfamily 2
Class Class 3858

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Cannabinoid receptor 1 Ligand Rimonabant Family 20 260
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Cannabinoid receptor 1 Ligand TM38837 Family 20 15
PHA848125 family 13 138
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Cannabinoid receptor 1 ligand AGN-PC-04YSUM family 7 6
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 4 inhibitor Su... 5 13
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 16
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 5-(2-... 6 83
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 34 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Cannabinoid receptor 1 ligand 5-(4-chlorophenyl)-1-(2,4-dichlo... 2 19
Cannabinoid receptor 1 ligand 5-(4-chlorophenyl)-1-(2,4-dichlo... 8 0
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
G1/S-specific cyclin-E2 and G1/S-specific cyclin-E1 inhibitor ... 5 10
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 5-(2-... 12 1
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 2-... 3 0
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Cannabinoid receptor 1 ligand SureCN4819820 family 11 5
Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-but... 20 13
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Mitogen-activated protein kinase 1 inhibitor Pyrrole Carboxami... 3 12
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN1298914... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
B1 bradykinin receptor ligand SureCN6045889 family 4 9
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
Cannabinoid receptor 1 ligand AGN-PC-07NHJ5 family 9 1
B1 bradykinin receptor ligand SureCN6045964 family 2 1
Mitogen-activated protein kinase 14 inhibitor SureCN14185127 f... 2 0
Cannabinoid receptor 1 ligand AGN-PC-07R5TU family 11 0
Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family 5 2
Cannabinoid receptor 1 ligand AGN-PC-07RA6C family 21 2
Cannabinoid receptor 1 ligand AGN-PC-07RA3R family 15 0
Cannabinoid receptor 1 ligand AGN-PC-07R6QS family 5 0
Cannabinoid receptor 1 ligand AGN-PC-07R9T4 family 27 0
Potassium voltage-gated channel subfamily A member 5 ligand [(... 7 28
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 7 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00392574 CHEMBL2441831 Bioactive 3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-6-(1-methylpyrazol-3-yl)-7H-pyrrolo[3,4-b]pyridin-5-one
CFAMM00392573 CHEMBL2441833 Bioactive 3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-6-[(1-methylpyrazol-3-yl)methyl]-7H-pyrrolo[3,4-b]pyridin-5-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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