CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9048
Family Name Renin and Cytochrome P450 3A4 inhibitor (3S,4R)-N-cyclopropyl-4-(3,4-difluorophenyl)-4-hydroxy-N-[[3-(2-methoxyethoxy)-5-(3-methoxypropyl)phenyl]methyl]piperidine-3-carboxamide family
No. of Seeds 4 No. of Other Members 10
Family Centroid CFAMM00361039 Functional Category Bioactive
Superfamily Substance-P receptor and Renin Binder Superfamily
Class Class 1769

Cousin Family NamesSeedsMembers
Renin inhibitor AGN-PC-07ZC01 family 12 16
Renin inhibitor SureCN1472318 family 4 1
Renin and Cytochrome P450 3A4 inhibitor (3R,4S)-N-[[2-chloro-5... 28 3
Renin and Potassium voltage-gated channel subfamily H member 2... 17 2
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Renin and Potassium voltage-gated channel subfamily H member 2... 6 0


External ID

Functional Category

Molecule Name

CFAMM00392580 CHEMBL1910291 Bioactive (3S,4R)-4-(4-chloro-3-fluorophenyl)-N-cyclopropyl-4-hydroxy-N-[[3-(2-methoxyethoxy)-5-(3-methoxypropyl)phenyl]methyl]piperidine-3-carboxamide
CFAMM00392585 CHEMBL1923111 Bioactive (3R,3'S)-N-cyclopropyl-5,6-difluoro-N-[[3-(2-methoxyethoxy)-5-(3-methoxypropyl)phenyl]methyl]spiro[1H-2-benzofuran-3,4'-piperidine]-3'-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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