CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9070
Family Name Serine/threonine-protein kinase pim-1 and Serine/threonine-protein kinase pim-3 inhibitor 5-[5-[6-[(2S)-2-aminobutoxy]pyrazin-2-yl]-1H-indol-3-yl]-6-fluoropyridin-2-amine family
No. of Seeds 7 No. of Other Members 0
Family Centroid CFAMM00392778 Functional Category Bioactive
Superfamily Casein kinase I isoform delta and Mitogen-activated protein kinase 14 Binder Superfamily
Class Class 920

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1


External ID

Functional Category

Molecule Name

CFAMM00392778 CHEMBL1910911 Bioactive 5-[5-[6-[(2S)-2-aminobutoxy]pyrazin-2-yl]-1H-indol-3-yl]-6-fluoropyridin-2-amine
CFAMM00392777 CHEMBL1910912 Bioactive 5-[5-[6-[(2S)-2-amino-3-methylbutoxy]pyrazin-2-yl]-1H-indol-3-yl]-6-fluoropyridin-2-amine
CFAMM00392776 CHEMBL1910913 Bioactive 5-[5-[6-[(2S)-2-amino-3,3-dimethylbutoxy]pyrazin-2-yl]-1H-indol-3-yl]-6-fluoropyridin-2-amine
CFAMM00392775 CHEMBL1910914 Bioactive 5-[5-[6-[(2S)-2-amino-2-phenylethoxy]pyrazin-2-yl]-1H-indol-3-yl]-6-fluoropyridin-2-amine
CFAMM00392774 CHEMBL1910915 Bioactive 5-[5-[6-[(2R)-2-amino-2-phenylethoxy]pyrazin-2-yl]-1H-indol-3-yl]-6-fluoropyridin-2-amine
CFAMM00392779 CHEMBL1910907 Bioactive 5-[5-[6-(4-aminocyclohexyl)oxypyrazin-2-yl]-1H-indol-3-yl]-6-fluoropyridin-2-amine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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