CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9077
Family Name Mitogen-activated protein kinase 14 inhibitor 6-[2-methyl-5-(5-methyl-1H-1,2,4-triazol-3-yl)phenyl]spiro[1H-indole-3,1'-cyclopentane]-2-one family
No. of Seeds 5 No. of Other Members 5
Family Centroid CFAMM00392838 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 8 and Mitogen-activated protein kinase 10 Binder Superfamily 6
Class Class 2684

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2


External ID

Functional Category

Molecule Name

CFAMM00392836 CHEMBL1911197 Bioactive 6-[2-methyl-5-(1H-1,2,4-triazol-5-yl)phenyl]spiro[1H-indole-3,1'-cyclopentane]-2-one
CFAMM00392842 CHEMBL1911332 Bioactive 4',4'-difluoro-6-[2-methyl-5-(5-methyl-1H-1,2,4-triazol-3-yl)phenyl]spiro[1H-indole-3,1'-cyclohexane]-2-one
CFAMM00392834 CHEMBL1911194 Bioactive 6-[2-methyl-5-(5-methyl-1H-1,2,4-triazol-3-yl)phenyl]spiro[1H-indole-3,4'-oxane]-2-one
CFAMM00392838 CHEMBL1911193 Bioactive 6-[2-methyl-5-(5-methyl-1H-1,2,4-triazol-3-yl)phenyl]spiro[1H-indole-3,1'-cyclopentane]-2-one
CFAMM00392843 CHEMBL1911333 Bioactive 6-[2-methyl-5-(5-methyl-1H-1,2,4-triazol-3-yl)phenyl]-1'-methylsulfonylspiro[1H-indole-3,4'-piperidine]-2-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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