CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9097
Family Name Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor 2-[2-chloro-4-(trifluoromethyl)phenoxy]-N-[(2R)-1-(4-methylpiperazin-1-yl)-1-oxo-3-phenylmethoxypropan-2-yl]pyridine-3-carboxamide family
No. of Seeds 10 No. of Other Members 15
Family Centroid CFAMM00392960 Functional Category Bioactive
Superfamily B1 bradykinin receptor and Cytochrome P450 3A4 Binder Superfamily
Class Class 1652

Cousin Family NamesSeedsMembers
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 2
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Somatostatin receptor type 5 ligand AGN-PC-088VSK family 2 3
5-hydroxytryptamine receptor 4 ligand AGN-PC-00GB52 family 5 2
5-hydroxytryptamine receptor 4 ligand 2-(4-pyridin-4-ylpiperaz... 2 1
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Sodium channel protein type 10 subunit alpha and Sodium channe... 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Survival motor neuron protein and Lysine-specific demethylase ... 1 1
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 7
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Growth hormone secretagogue receptor type 1 and Potassium volt... 2 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 3
G-protein coupled bile acid receptor 1 ligand (4-cyclopropyl-2... 10 13
G-protein coupled bile acid receptor 1 ligand (4-cyclopropyl-2... 2 1
G-protein coupled bile acid receptor 1 ligand (4-cyclopropyl-2... 1 2
Motilin receptor ligand SureCN2768193 family 2 1
Motilin receptor ligand SureCN2765637 family 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 6 1
5-hydroxytryptamine receptor 4 ligand 4-amino-5-chloro-N-[1-[8... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Acyl-CoA desaturase inhibitor 3-[[2-[4-(2-chlorophenoxy)piperi... 8 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00392961 CHEMBL1911816 Bioactive 2-(4-chloro-2-methylphenoxy)-N-[(2R)-1-(4-methylpiperazin-1-yl)-1-oxo-3-phenylmethoxypropan-2-yl]pyridine-3-carboxamide
CFAMM00392967 CHEMBL1911814 Bioactive 2-(2,4-dichlorophenoxy)-5-fluoro-N-[(2R)-1-(4-methylpiperazin-1-yl)-1-oxo-3-phenylmethoxypropan-2-yl]pyridine-3-carboxamide
CFAMM00392960 CHEMBL1911817 Bioactive 2-[2-chloro-4-(trifluoromethyl)phenoxy]-N-[(2R)-1-(4-methylpiperazin-1-yl)-1-oxo-3-phenylmethoxypropan-2-yl]pyridine-3-carboxamide
CFAMM00392959 CHEMBL1911826 Bioactive 2-[2-chloro-4-(trifluoromethyl)phenoxy]-N-[(2R)-1-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-1-oxo-3-phenylmethoxypropan-2-yl]pyridine-3-carboxamide
CFAMM00392958 CHEMBL1911815 Bioactive 2-(2,4-dichlorophenoxy)-N-[(2R)-1-(4-methylpiperazin-1-yl)-1-oxo-3-phenylmethoxypropan-2-yl]pyridine-3-carboxamide
CFAMM00392951 CHEMBL1911827 Bioactive 2-[2-chloro-4-(trifluoromethyl)phenoxy]-N-[(2R)-1-[(3R)-3-(methylamino)pyrrolidin-1-yl]-1-oxo-3-phenylmethoxypropan-2-yl]pyridine-3-carboxamide
CFAMM00392944 CHEMBL1911829 Bioactive N-[(2R)-1-[[(3S)-1-azabicyclo[2.2.2]octan-3-yl]amino]-1-oxo-3-phenylmethoxypropan-2-yl]-2-[2-chloro-4-(trifluoromethyl)phenoxy]pyridine-3-carboxamide
CFAMM00392963 CHEMBL1911818 Bioactive 2-[2-chloro-4-(trifluoromethyl)phenoxy]-N-[(2R)-3-(2,3-dihydro-1,4-benzodioxin-6-ylmethoxy)-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]pyridine-3-carboxamide
CFAMM00392962 CHEMBL1911819 Bioactive 2-[2-chloro-4-(trifluoromethyl)phenoxy]-N-[(2R)-3-[(4-fluorophenyl)methoxy]-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]pyridine-3-carboxamide
CFAMM00392955 CHEMBL1911830 Bioactive N-[(2R)-1-[[(3R)-1-azabicyclo[2.2.2]octan-3-yl]amino]-1-oxo-3-phenylmethoxypropan-2-yl]-2-[2-chloro-4-(trifluoromethyl)phenoxy]pyridine-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

44589 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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