CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM91
Family Name Sigma non-opioid intracellular receptor 1 and Kappa-type opioid receptor ligand 2-[(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)methyl]-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indole-8-carbonitrile family
No. of Seeds 3 No. of Other Members 12
Family Centroid CFAMM00306995 Functional Category Bioactive with Natural Product
Superfamily Sodium-dependent serotonin transporter and D(2) dopamine receptor Binder Superfamily
Class Class 3075

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
Glucocorticoid receptor ligand SureCN4194063 family 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
Sodium-dependent serotonin transporter and D(2) dopamine recep... 3 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 4 1
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 1 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
Transient receptor potential cation channel subfamily V member... 3 2
Melanin-concentrating hormone receptor 1 ligand 6-[3-methoxy-4... 5 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00306995 CHEMBL101535 Bioactive 2-[(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)methyl]-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indole-8-carbonitrile
CFAMM00307001 CHEMBL323088 Bioactive 8-[[8-(hydroxymethyl)-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indol-2-yl]methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
CFAMM00307000 CHEMBL317433 Bioactive AGN-PC-074ULK

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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