CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM910
Family Name Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 inhibitor AGN-PC-07ZD0T family
No. of Seeds 2 No. of Other Members 4
Family Centroid CFAMM00285234 Functional Category Bioactive
Superfamily D(3) dopamine receptor Ligand SB-277011 Superfamily
Class Class 840

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Prothrombin Inhibitor Ximelegatran Family 8 157
Neuromedin-K receptor Ligand SB222200 Family 17 235
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 6
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 1 0
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Serine/threonine-protein kinase mTOR and DNA-dependent protein... 6 7
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 5 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 2
Histamine H3 receptor ligand SureCN1857507 family 1 4
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
B1 bradykinin receptor ligand 5-(8-chloro-4-methyl-1-oxophthal... 1 0
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 1 0
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 3 2
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Gonadotropin-releasing hormone receptor ligand 6-[(4-chloro-2-... 3 3
Motilin receptor ligand SureCN2768052 family 3 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Substance-P receptor ligand AGN-PC-004REJ family 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[4-oxo-3-(4-p... 2 1
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Cytochrome P450 2C9 inhibitor AGN-PC-04XDND family 1 3
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Serine/threonine-protein kinase mTOR inhibitor SureCN7919590 f... 1 1
Serine/threonine-protein kinase mTOR inhibitor 1-[4-[4-(oxan-2... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27515 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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