CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9114
Family Name Melanin-concentrating hormone receptor 1 ligand 1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butan-1-one family
No. of Seeds 8 No. of Other Members 4
Family Centroid CFAMM00393089 Functional Category Bioactive
Superfamily Melanin-concentrating hormone receptor 1 Binder Superfamily 5
Class Class 2042

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake and Serotonin re-uptake inhibitor phen... 18 41
D(2) dopamine receptor Ligand Haloperidol Family 5 53
Delta-type opioid receptor Ligand Loperamide Family 8 55
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
DNA Binder Procarbazine Family 8 358
Neuromedin-K receptor Ligand Osanetant Family 38 192
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Liver carboxylesterase 1 Inhibitor 1-(4-chloro-phenyl)-2-pheny... 5 47
Sodium-dependent dopamine transporter and Sodium-dependent nor... 10 28
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 4 10
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Sigma non-opioid intracellular receptor 1 ligand N-Phprop-clph... 1 12
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... 1 7
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 2 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
D(2) dopamine receptor and Sigma non-opioid intracellular rece... 1 1
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 1
Histamine H3 receptor ligand AGN-PC-01WA6E family 10 1
5-hydroxytryptamine receptor 1A ligand [(7S,8R)-7-(dipropylami... 4 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
Melanocortin receptor 4 ligand 1-(4-chlorophenyl)-3-[4-[2-(4-f... 2 0
Histone deacetylase 6 inhibitor AGN-PC-0C5HOH family 1 1


External ID

Functional Category

Molecule Name

CFAMM00393086 CHEMBL1914630 Bioactive 4-[4-(4-chlorophenyl)piperidin-1-yl]-1-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)butan-1-one
CFAMM00393085 CHEMBL1914633 Bioactive 4-[4-(4-chlorophenyl)piperidin-1-yl]-1-[3-(cyclopropanecarbonyl)-1,2,4,5-tetrahydro-3-benzazepin-7-yl]butan-1-one
CFAMM00393091 CHEMBL1914623 Bioactive 4-[4-(4-chlorophenyl)piperidin-1-yl]-1-(3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)butan-1-one
CFAMM00393084 CHEMBL1914632 Bioactive 1-(3-butanoyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butan-1-one
CFAMM00393083 CHEMBL1914639 Bioactive 7-[4-[4-(4-chlorophenyl)piperidin-1-yl]butanoyl]-N-ethyl-1,2,4,5-tetrahydro-3-benzazepine-3-carboxamide
CFAMM00393089 CHEMBL1914629 Bioactive 1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butan-1-one
CFAMM00393087 CHEMBL1914631 Bioactive 4-[4-(4-chlorophenyl)piperidin-1-yl]-1-(3-propanoyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)butan-1-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

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Professor in Department of Pharmacy
National University of Singapore, Singapore

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