CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9119
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform inhibitor N-[2-chloro-5-(3-piperidin-1-ylquinoxalin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamide family
No. of Seeds 15 No. of Other Members 3
Family Centroid CFAMM00393122 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and Tyrosine-protein kinase JAK2 Binder Superfamily
Class Class 122

Cousin Family NamesSeedsMembers
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
NF-kappa-B Inhibitor 9-chloro-5h-6-thia-4,5-diaza-chrysene 6,6... 3 27
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 13 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 15
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Bombesin receptor subtype-3 ligand 2-[3-[6-(4-tert-butylphenyl... 7 1
Bombesin receptor subtype-3 and Nuclear receptor subfamily 1 g... 12 11
Bombesin receptor subtype-3 and Nuclear receptor subfamily 1 g... 3 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00393128 CHEMBL1914731 Bioactive N-[2-chloro-5-[3-(cyclohexylmethylamino)quinoxalin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00393121 CHEMBL1914739 Bioactive N-[2-chloro-5-[3-(4,4-difluoropiperidin-1-yl)quinoxalin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00393135 CHEMBL1914741 Bioactive N-[2-chloro-5-[3-(4-methoxypiperidin-1-yl)quinoxalin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00393127 CHEMBL1914732 Bioactive N-[5-[3-[benzyl(methyl)amino]quinoxalin-6-yl]-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00393134 CHEMBL1914740 Bioactive N-[5-[3-(3-azabicyclo[3.2.2]nonan-3-yl)quinoxalin-6-yl]-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00393126 CHEMBL1914733 Bioactive N-[2-chloro-5-[3-(piperidin-3-ylmethylamino)quinoxalin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00393133 CHEMBL1914729 Bioactive N-[2-chloro-5-[3-(2-methoxyethylamino)quinoxalin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00393125 CHEMBL1914734 Bioactive N-[2-chloro-5-[3-(2-phenylethylamino)quinoxalin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00393124 CHEMBL1914735 Bioactive N-[2-chloro-5-[3-(2-piperidin-1-ylethylamino)quinoxalin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00393123 CHEMBL1914737 Bioactive N-[2-chloro-5-[3-(dimethylamino)quinoxalin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00393129 CHEMBL1914730 Bioactive N-[2-chloro-5-[3-[2-methoxyethyl(methyl)amino]quinoxalin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00393122 CHEMBL1914738 Bioactive N-[2-chloro-5-(3-piperidin-1-ylquinoxalin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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