CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9121
Family Name Histamine H4 receptor ligand 8-fluoro-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-[1]benzofuro[3,2-d]pyrimidin-2-amine family
No. of Seeds 6 No. of Other Members 1
Family Centroid CFAMM00393155 Functional Category Bioactive
Superfamily Hepatocyte growth factor receptor and Mast/stem cell growth factor receptor Kit Ligand MP470 Superfamily
Class Class 899

Cousin Family NamesSeedsMembers
Kinetin family 2 39
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
MK-3328 family 2 32
Adenosine receptor A1 and Adenosine receptor A2a Ligand CGS-15... 24 47
Mitogen-activated protein kinase 14 Inhibitor CP-808844 Family 39 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Divapl... 3 47
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Histamine H4 receptor and Histamine H3 receptor ligand SureCN6... 17 51
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Survival motor neuron protein and Neuropeptide S receptor liga... 1 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 5 8
Adenosine receptor A2b and Adenosine receptor A2a ligand AGN-P... 2 0
Adenosine kinase inhibitor 7-[(4aS,7aS)-6-benzyl-3,4,4a,5,7,7a... 2 1
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
5-hydroxytryptamine receptor 1F ligand AGN-PC-075AYH family 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 5
Histamine H4 receptor ligand 8-chloro-4-[(3R)-3-(methylamino)p... 1 1
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1938684 ... 5 6
Prothrombin inhibitor SureCN6925359 family 6 18
Adenosine receptor A2a ligand 9-[(6-chloro-1,3-benzodioxol-5-y... 1 0
Histamine H3 receptor ligand N-[[2-[2-[(2R)-2-methylpyrrolidin... 4 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 29 1
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 3 0
Platelet-activating factor receptor ligand AGN-PC-00GDIY family 1 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 0
Metabotropic glutamate receptor 5 ligand AGN-PC-09QKEE family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00393156 CHEMBL1914783 Bioactive 4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-8-(trifluoromethyl)-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00393155 CHEMBL1914782 Bioactive 8-fluoro-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00393152 CHEMBL1914776 Bioactive 4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00393151 CHEMBL1914778 Bioactive 9-fluoro-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00393150 CHEMBL1914755 Bioactive 4-(4-methylpiperazin-1-yl)-8-(trifluoromethyl)-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00393157 CHEMBL1914781 Bioactive 8-bromo-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-[1]benzofuro[3,2-d]pyrimidin-2-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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