CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9127
Family Name Histamine H4 receptor and Histamine H3 receptor ligand (E)-[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(5-fluorobenzimidazol-2-ylidene)methanamine family
No. of Seeds 4 No. of Other Members 3
Family Centroid CFAMM00393183 Functional Category Bioactive
Superfamily Menin and Prelamin-A/C Binder Superfamily 24
Class Class 829

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Histamine H1 receptor Ligand Mizolastine Family 14 603
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Tryptase Inhibitor Babim Family 12 90
Cathepsin D Inhibitor 1h-benoximidazole-2-carboxylic Acid Family 1 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... 2 12
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Farnesyl pyrophosphate synthase Inhibitor [2-(benzoimidazol-1-... 2 16
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Histamine H4 receptor ligand SureCN602132 family 1 8
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Neuropeptide Y receptor type 5 ligand 8-[6-(4-fluorophenyl)-1H... 2 1
Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperid... 2 8
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 2
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 3
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... 2 13
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1H-benzimidazo... 3 5
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00BSP9 ... 6 12
Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... 2 4
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Putative Bioactive N-[(2R)-2-[(2S)-2-(1H-benzimidazol-2-yl)pyr... 2 0
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
D(2) dopamine receptor ligand 4-bromo-6-[2-[4-[3-(trifluoromet... 1 2
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 1 0
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 7
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 1
Putative NP ZINC00490623 Family 6 0
1H-benzimidazol-2-ylmethyl(hydroxy)phosphinate NP Agn-pc-05gr7... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00393185 CHEMBL1938975 Bioactive (E)-[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(5-fluoro-4-methylbenzimidazol-2-ylidene)methanamine
CFAMM00393183 CHEMBL1938977 Bioactive (E)-[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(5-fluorobenzimidazol-2-ylidene)methanamine
CFAMM00393188 CHEMBL1915348 Bioactive [(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(5,6-difluorobenzimidazol-2-ylidene)methanamine
CFAMM00393186 CHEMBL1938979 Bioactive [(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(benzimidazol-2-ylidene)methanamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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