CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFBM9128
Family Name Serine/threonine-protein kinase pim-2 and Serine/threonine-protein kinase pim-1 inhibitor N-(2-fluorophenyl)-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amine family
No. of Seeds 9 No. of Other Members 2
Family Centroid CFAMM00149616 Functional Category Bioactive
Superfamily Aurora kinase B and Tyrosine-protein kinase Lck Binder Superfamily
Class Class 1024

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Type-1 angiotensin II receptor Ligand Forasartan Family 3 253
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
RAC-gamma serine/threonine-protein kinase and Ribosomal protei... 3 5
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Hepatocyte growth factor receptor Ligand SGX523 Family 1 15
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
HER Inhibitor AC480 Family 4 67
Vascular endothelial growth factor receptor 2 Ligand Ptk787/zk... 5 38
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Reverse transcriptase Inhibitor Dapivirine Family 5 72
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Gamma-aminobutyric acid A receptor Ligand Ocinaplon Family 1 10
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
GDC-0349 family 44 77
Aurora kinase A Inhibitor ABT-348 Family 20 49
SCH-900776 family 8 14
PF-4217903 family 14 65
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 F... 11 20
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Metabotropic glutamate receptor 5 Ligand 3-(1-pyridin-2-yl-1h-... 3 6
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Adenosine kinase inhibitor abt-702 family 14 1
Prothrombin inhibitor SureCN5856722 family 3 16
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 2
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Xanthine dehydrogenase/oxidase inhibitor AGN-PC-06VJIZ family 1 2
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 13
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
Transient receptor potential cation channel subfamily V member... 1 0
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
Adenosine receptor A3 ligand 5-butyl-8-(4-methylsulfanylphenyl... 2 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M46L fa... 2 7
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... 24 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Serine/threonine-protein kinase B-raf inhibitor SureCN1013857 ... 9 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Cellular tumor antigen p53 inhibitor CHEMBL1318500 family 1 0
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14574... 1 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Serine/threonine-protein kinase Chk1 and Cyclin-A2 inhibitor S... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Corticotropin-releasing factor receptor 1 ligand SureCN6301726... 4 1
Insulin-like growth factor 1 receptor and Insulin receptor lig... 1 1
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 5-[4-... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 9 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 4
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 1 4
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(1H-pyr... 2 8
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 8-... 6 2
Vasopressin V1a receptor ligand 2-[4-[4-[(3-chlorophenyl)methy... 1 0
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 0
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Tyrosine-protein kinase JAK2 and ALK tyrosine kinase receptor ... 5 0
Tyrosine-protein kinase JAK2 inhibitor N-[2-[2-[3-chloro-4-(4-... 2 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Vascular endothelial growth factor receptor 2 and Fibroblast g... 5 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[(3S)-3-[(4... 2 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... 2 13
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 12 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 1
Transient receptor potential cation channel subfamily V member... 4 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 11 0
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Casein kinase II subunit alpha inhibitor 7-(cyclopropylamino)-... 1 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... 3 3
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 4 2
Transient receptor potential cation channel subfamily V member... 4 0
Fibroblast growth factor receptor 1 and Vascular endothelial g... 5 0
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Cyclin-dependent kinase 2 and MAP kinase-activated protein kin... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 1
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Metabotropic glutamate receptor 2 ligand 3-(cyclopropylmethyl)... 1 1
Scavenger receptor class B member 1 ligand 9-[3-(4,6-diethylpy... 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 4 2
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Somatostatin receptor type 3 and Somatostatin receptor type 4 ... 5 1
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 4 8
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 2,... 4 4
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... 3 0
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
Protein kinase C theta type and Protein kinase C delta type in... 2 1
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Epithelial discoidin domain-containing receptor 1 and Mast/ste... 1 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-chloro... 2 0
Motilin receptor ligand SureCN2004322 family 2 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 8
Mast/stem cell growth factor receptor Kit and Proto-oncogene t... 3 5
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 9 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Cytochrome P450 3A4 and Cytochrome P450 2C8 inhibitor N-[3-[(1... 1 0
Tyrosine-protein kinase JAK2 inhibitor [4-[[5-(1-ethylpyrazol-... 2 3
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
ALK tyrosine kinase receptor ligand 3-[1-[(3-fluorophenyl)meth... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
D(3) dopamine receptor and Muscarinic acetylcholine receptor M... 8 2
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cyclin-dependent kinase 1 inhibitor N-[[5-[(3Z)-3-[4-(methoxym... 3 7
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-met... 2 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1-met... 2 0
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-(1,2,4-triazol... 2 1
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 4
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 0
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Mitogen-activated protein kinase 14 inhibitor SureCN294394 family 2 6
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Adenosine receptor A3 ligand SureCN6716937 family 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Nociceptin receptor and Mu-type opioid receptor ligand SureCN5... 1 0
Epidermal growth factor receptor ligand AGN-PC-073LJS family 4 0
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 3 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
High affinity nerve growth factor receptor ligand SureCN333709... 4 5
High affinity nerve growth factor receptor ligand SureCN490352... 3 0
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Mitogen-activated protein kinase 8 inhibitor N-[4-[4-[2-(cyclo... 1 0
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[2-... 9 0
Gonadotropin-releasing hormone receptor ligand AGN-PC-00AWCA f... 1 0
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
Adenosine receptor A2a ligand AGN-PC-0756RB family 1 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
P2X purinoceptor 7 inhibitor 3-[[5-(2,3-dichlorophenyl)tetrazo... 2 1
Serine/threonine-protein kinase PLK1 inhibitor 2-amino-pyrazol... 2 0


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Functional Category

Molecule Name

CFAMM00393190 CHEMBL1915634 Bioactive N-(4-fluoro-2-methylphenyl)-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amine
CFAMM00393189 CHEMBL1915635 Bioactive N-(5-fluoro-2-methylphenyl)-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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