CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9135
Family Name cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A inhibitor 2-bromo-6-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]pyridine family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00393215 Functional Category Bioactive
Superfamily D(2) dopamine receptor and Prelamin-A/C Binder Superfamily
Class Class 2208

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
PF-02545920 family 16 140
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Sigma non-opioid intracellular receptor 1 ligand 1'-butyl-6-me... 23 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
Smoothened homolog inhibitor AGN-PC-088VBV family 1 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 9 1
Sigma non-opioid intracellular receptor 1 ligand 6-methoxy-1'-... 2 0
Muscarinic acetylcholine receptor M3 ligand 3-fluoro-2-(3-pipe... 3 1
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Platelet-derived growth factor receptor beta and Receptor-type... 1 2
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Platelet-derived growth factor receptor beta and Macrophage co... 8 0
D(3) dopamine receptor and D(2) dopamine receptor ligand Piper... 3 14
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 inhibi... 1 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
Prostaglandin D2 receptor 2 ligand 2-[4-(difluoromethoxy)-2-et... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor AGN-... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN4806204 f... 13 7
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
B2 bradykinin receptor ligand SureCN13145573 family 7 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
RAC-alpha serine/threonine-protein kinase and Rho-associated p... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00393215 CHEMBL1915730 Bioactive 2-bromo-6-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]pyridine
CFAMM00393217 CHEMBL1915729 Bioactive 5-methoxy-2-[[4-[4-pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]pyridine
CFAMM00393216 CHEMBL1915738 Bioactive 5-bromo-2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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