CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9138
Family Name cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A inhibitor CHEMBL1915904 family
No. of Seeds 7 No. of Other Members 4
Family Centroid CFAMM00393229 Functional Category Bioactive
Superfamily Corticotropin-releasing factor receptor 1 and cAMP Binder Superfamily
Class Class 3054

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Oxytocin receptor and Vasopressin V1a receptor Ligand PF-32741... 4 36
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 6
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase JAK2 inhibitor N-[3-chloro-4-(4-methyl... 2 1
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 5 8
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 7 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 18 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Metabotropic glutamate receptor 2 ligand 8-chloro-3-(cycloprop... 6 2
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Oxytocin receptor and Vasopressin V1b receptor ligand AGN-PC-0... 1 1
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Oxytocin receptor ligand AGN-PC-07C71T family 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00393229 CHEMBL1915904 Bioactive CHEMBL1915904

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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