CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM914
Family Name 5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine receptor 3B ligand AGN-PC-074XPW family
No. of Seeds 10 No. of Other Members 4
Family Centroid CFAMM00317126 Functional Category Bioactive
Superfamily Phospholipase A2, membrane associated and Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J33) Binder Superfamily
Class Class 297

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Dihydroorotate dehydrogenase Inhibitor Cinchoninic Acid Family 1 21
Leukotriene B4 receptor 1 Ligand SB-201993 Family 5 13
Integrin beta-3 Inhibitor L-756568 Family 8 59
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Lethal factor Inhibitor 3-(2,5-dimethyl-1h-pyrrol-1-yl)benzoic... 2 44
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family 3 20
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Metabotropic glutamate receptor 5 Ligand 6-phenylethynyl-nicot... 2 26
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
5-hydroxytryptamine receptor 3A Ligand 3alpha-(1'-methyl-2'-in... 2 17
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Adenosine receptor A3 and Adenosine receptor A1 ligand propyl ... 6 63
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Sodium-dependent serotonin transporter and D(2) dopamine recep... 13 2
NS5B protein inhibitor AC1NQMYG family 6 12
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4R,... 3 7
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
Histamine H3 receptor ligand (4S)-7-bromo-4-methyl-8-(1-propan... 2 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
Pol polyprotein and Protease inhibitor Palinavir family 1 0
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
NS5B protein inhibitor AC1O5AET family 3 1
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[2-(1H-ind... 1 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 9 6
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
C-C chemokine receptor type 5 ligand N-methyl-4-[6-methyl-5-[[... 2 2
5-hydroxytryptamine receptor 4 ligand N-[[1-[[4-[2-(2H-tetrazo... 2 0
5-hydroxytryptamine receptor 4 and Potassium voltage-gated cha... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 8 0
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 1 3
Cyclin-dependent kinase 2 and Vascular endothelial growth fact... 1 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
Histamine H3 receptor ligand SureCN1397929 family 1 1
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Glycine receptor subunit alpha-1 ligand [(1R,5R)-8-azabicyclo[... 2 10
DNA polymerase beta and Microtubule-associated protein tau inh... 1 1
Potassium-transporting ATPase alpha chain 1 and Potassium-tran... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00317137 CHEMBL113742 Bioactive SureCN9199896
CFAMM00317117 CHEMBL148398 Bioactive SureCN7435346
CFAMM00317126 CHEMBL111059 Bioactive AGN-PC-074XPW
CFAMM00317134 CHEMBL148076 Bioactive SureCN9202837
CFAMM00317125 CHEMBL112941 Bioactive AGN-PC-074XQJ
CFAMM00317133 CHEMBL321477 Bioactive AGN-PC-074XPV
CFAMM00317115 CHEMBL109322 Bioactive AGN-PC-074Y2Q
CFAMM00317122 CHEMBL148430 Bioactive 145082-87-7
CFAMM00317127 CHEMBL423687 Bioactive SureCN9197926
CFAMM00317121 CHEMBL325235 Bioactive SureCN9203192

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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