CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9152
Family Name cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A and cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor 8-fluoro-6-methoxy-3,4-dimethyl-1-(2-methylphenyl)imidazo[1,5-a]quinoxaline family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00313845 Functional Category Bioactive
Superfamily cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A and cGMP-dependent 3',5'-cyclic phosphodiesterase Binder Superfamily 2
Class Class 3054

Cousin Family NamesSeedsMembers
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Extracellular calcium-sensing receptor ligand SureCN2503512 fa... 3 17
Extracellular calcium-sensing receptor ligand SureCN2503519 fa... 1 0
Extracellular calcium-sensing receptor ligand SureCN2972008 fa... 4 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 16 3
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 7 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 7 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
5-hydroxytryptamine receptor 1A and Gonadotropin-releasing hor... 3 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
Extracellular calcium-sensing receptor ligand SureCN2498142 fa... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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