Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71 Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263 Plitidepsin family 15 5 Flovagatran family 12 546 Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104 Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348 Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55 Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13 Disintegrin and metalloproteinase domain-containing protein 17... 25 36 Integrin beta-3 Inhibitor RWJ-53419 Family 6 65 Plasmepsin-1 Inhibitor SC-5003 Family 93 173 Neuromedin-K receptor Ligand PD-160946 Family 10 32 72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12 Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11 Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26 Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6 Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18 Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36 Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2 Vasopressin V1a receptor Ligand Vasopressin Analogue Family 4 3 Pol polyprotein inhibitor 180968-31-4 family 8 13 Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26 Beta-secretase 1 and Cathepsin D inhibitor (1R,3S)-N-[(2S,3S)-... 2 25 Substance-P receptor ligand (1S,2R,5aS,7R,8aR,8bS)-2-[(1R)-1-[... 11 15 Substance-P receptor ligand (1S,2R,5aS,7S,8aR,8bS)-7-amino-2-[... 12 2 Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5 Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1 Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 3 1 Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10 Pol polyprotein inhibitor benzyl N-[(2S,3R)-4-[(3aR,6S,7aS)-6-... 3 2 Pol polyprotein inhibitor AC1LADQG family 7 1 Pol polyprotein inhibitor methyl (2S)-2-[[(2S,3R)-2-[[1-[(2R,3... 1 0 Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3 Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 3 3 Beta-secretase 1 inhibitor (2S)-2-[(3R)-3-acetamido-3-(2-methy... 3 0 Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 11 Pol polyprotein inhibitor benzyl N-[(2S)-4-amino-1-[[(2S,3R)-4... 2 1 Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 13 3 Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1 Beta-secretase 1 and Cathepsin D inhibitor (4S)-N-[(2S,3R)-4-[... 3 0 Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8 Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 2 0 Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0 Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00393293 CHEMBL1916157 Bioactive
(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenoxypyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide CFAMM00393298 CHEMBL1916168 Bioactive
(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-[(2R,4R)-4-[(4-fluorophenyl)methoxy]pyrrolidin-2-yl]-1-hydroxypropan-2-yl]-4-phenylbutanamide CFAMM00393297 CHEMBL1916167 Bioactive
(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-1-[(2R,4R)-4-[(3-cyanophenyl)methoxy]pyrrolidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-4-phenylbutanamide CFAMM00393296 CHEMBL1916166 Bioactive
(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-[[3-(trifluoromethyl)phenyl]methoxy]pyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00393302 CHEMBL403727 Bioactive
1-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenoxypyrrolidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide CFAMM00393299 CHEMBL403195 Bioactive
N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenoxypyrrolidin-2-yl]propan-2-yl]-3-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-5-methylbenzamide CFAMM00393301 CHEMBL271249 Bioactive
(3S)-1-benzyl-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenylmethoxypyrrolidin-2-yl]propan-2-yl]-5-oxopyrrolidine-3-carboxamide CFAMM00393294 CHEMBL402307 Bioactive
(3S)-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenylmethoxypyrrolidin-2-yl]propan-2-yl]-1-[(3-methylphenyl)methyl]-5-oxopyrrolidine-3-carboxamide CFAMM00393300 CHEMBL402374 Bioactive
(3S)-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenylmethoxypyrrolidin-2-yl]propan-2-yl]-1-[(3-fluorophenyl)methyl]-5-oxopyrrolidine-3-carboxamide CFAMM00393295 CHEMBL255602 Bioactive
(3S)-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenylmethoxypyrrolidin-2-yl]propan-2-yl]-1-[(2-fluorophenyl)methyl]-5-oxopyrrolidine-3-carboxamide
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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