CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9156
Family Name Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-(pyridin-3-ylmethoxy)pyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00393305 Functional Category Bioactive
Superfamily Beta-secretase 1 and Growth hormone secretagogue receptor type 1 Binder Superfamily
Class Class 137

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Indinavir Family 36 211
HIV-1 protease Inhibitor Atazanavir Family 16 58
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Plasmepsin-2 Inhibitor KNI-10526 Family 8 10
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 22
Plasmepsin-1 and Plasmepsin-2 inhibitor Statine-like inhibitor... 13 5
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 8 8
Beta-3 adrenergic receptor ligand N-[4-[2-[[(2R)-2-hydroxy-2-p... 1 10
Pol polyprotein and Protease inhibitor Palinavir family 1 0
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Pol polyprotein inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-N-... 7 3
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-2-(benzenesulfo... 3 0
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-4-[[(4S)... 34 23
Pol polyprotein inhibitor AC1LAHRX family 4 0
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0
Beta-secretase 1 and Cytochrome P450 3A4 inhibitor N-[(2S,3R)-... 3 7
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7013744... 2 3
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Pol polyprotein inhibitor Palinavir deriv. 13 family 1 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Gastrin/cholecystokinin type B receptor ligand CHEMBL338525 fa... 1 10
Renin inhibitor SureCN7300793 family 2 5
Pol polyprotein inhibitor N-benzyl-2,2-difluoro-4-[[(2S)-3-met... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00393305 CHEMBL1916170 Bioactive (2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-(pyridin-3-ylmethoxy)pyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
CFAMM00393304 CHEMBL1916158 Bioactive (2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-pyridin-2-yloxypyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
CFAMM00393310 CHEMBL1916169 Bioactive (2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-(pyridin-2-ylmethoxy)pyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
CFAMM00393303 CHEMBL1916159 Bioactive (2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-pyridin-3-yloxypyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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